Document Detail


Patterns of spiral tip motion in cardiac tissues.
MedLine Citation:
PMID:  12779717     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In support of the spiral wave theory of reentry, simulation studies and animal models have been utilized to show various patterns of spiral wave tip motion such as meandering and drifting. However, the demonstration of these or any other patterns in cardiac tissues have been limited. Whether such patterns of spiral tip motion are commonly observed in fibrillating cardiac tissues is unknown, and whether such patterns form the basis of ventricular tachycardia or fibrillation remain debatable. Using a computerized dynamic activation display, 108 episodes of atrial and ventricular tachycardia and fibrillation in isolated and intact canine cardiac tissues, as well as in vitro swine and myopathic human cardiac tissues, were analyzed for patterns of nonstationary, spiral wave tip motion. Among them, 46 episodes were from normal animal myocardium without pharmacological perturbations, 50 samples were from normal animal myocardium, either treated with drugs or had chemical ablation of the subendocardium, and 12 samples were from diseased human hearts. Among the total episodes, 11 of them had obvious nonstationary spiral tip motion with a life span of >2 cycles and with consecutive reentrant paths distinct from each other. Four patterns were observed: (1) meandering with an inward petal flower in 2; (2) meandering with outward petals in 5; (3) irregularly concentric in 3 (core moving about a common center); and (4) drift in 1 (linear core movement). The life span of a single nonstationary spiral wave lasted no more than 7 complete cycles with a mean of 4.6+/-4.3, and a median of 4.5 cycles in our samples. Conclusion: (1) Patently evident nonstationary spiral waves with long life spans were uncommon in our sample of mostly normal cardiac tissues, thus making a single meandering spiral wave an unlikely major mechanism of fibrillation in normal ventricular myocardium. (2) A tendency toward four patterns of nonstationary spiral tip motion was observed. (c) 1998 American Institute of Physics.
Authors:
Dave T. Kim; Yvonne Kwan; John J. Lee; Takanori Ikeda; Takumi Uchida; Kamyar Kamjoo; Young-Hoon Kim; James J. C. Ong; Charles A. Athill; Tsu-Juey Wu; Lawrence Czer; Hrayr S. Karagueuzian; Peng-Sheng Chen
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Chaos (Woodbury, N.Y.)     Volume:  8     ISSN:  1089-7682     ISO Abbreviation:  Chaos     Publication Date:  1998 Mar 
Date Detail:
Created Date:  2003-Jun-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100971574     Medline TA:  Chaos     Country:  -    
Other Details:
Languages:  ENG     Pagination:  137-148     Citation Subset:  -    
Affiliation:
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center,UCLA School of Medicine, Los Angeles, California 90048.
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