| Patterns of relapse in patients with small cell carcinoma of the lung treated with adriamycin-cyclophosphamide chemotherapy and radiation therapy. | |
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MedLine Citation:
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PMID: 218736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-seven patients with small cell carcinoma of the lung were treated sequentially with induction chemotherapy (adriamycin and cyclophosphamide), radiation therapy (chest and whole-brain), and then maintenance chemotherapy for 2 years. Twenty responding patients were followed to relapse and patterns of recurrence were observed. This combined treatment resulted in a complete remission rate of 80% and a median survival of 565 days in limited-disease patients. Relapse overwhelmingly occurred in the chest, but patients receiving higher-dose radiation (4000-4500 rads in split-course) had a significant prolongation of time to recurrence compared to patients receiving 3000 rads in a single course of radiation (540 versus 270 days). Despite a long mean survival, only one limited-disease patient relapsed outside of the brain or chest, suggesting that chemotherapy had a good protective effect against micrometastatic disease. Three patients relapsed in the brain at 330, 450, and 520 days, suggesting that in future studies the prophylactic whole-brain radiation (3000 rads) should be intensified. |
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Authors:
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L J McMahon; T S Herman; M R Manning; J C Dean |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer treatment reports Volume: 63 ISSN: 0361-5960 ISO Abbreviation: Cancer Treat Rep Publication Date: 1979 Mar |
Date Detail:
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Created Date: 1979-06-29 Completed Date: 1979-06-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607107 Medline TA: Cancer Treat Rep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 359-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Small Cell
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drug therapy*,
radiotherapy Cyclophosphamide / therapeutic use* Doxorubicin / therapeutic use* Evaluation Studies as Topic Humans Lung Neoplasms / drug therapy*, radiotherapy Neoplasm Metastasis Neoplasm Recurrence, Local Remission, Spontaneous |
| Chemical | |
Reg. No./Substance:
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23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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