| Patterns and outcomes of drug-eluting coronary stent use in clinical practice. | |
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MedLine Citation:
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PMID: 16875917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine patterns and outcomes of drug-eluting stents (DES) use in clinical practice. BACKGROUND: DES are technology associated with superior outcomes. The initial limited availability and high cost of DES had the potential to influence their use. METHODS: Data from the American College of Cardiology-National Cardiovascular Data Registry were examined to describe the patterns of DES use in 408,033 percutaneous coronary intervention (PCI) procedures at 383 sites. Predictors of DES use were determined, and inhospital outcomes were examined. RESULTS: From April 2003 through December 2004, the proportion of procedures using DES increased from 19.7% to 78.2%. DES use increased across all patient groups and hospital types, but adoption was slower among older patients and those without health insurance. DES use varied among hospitals such that use was lower at rural and low-volume hospitals. Multivariable regression demonstrated a progressive decrease in the odds of DES use as age increased. White race, female sex, presence of insurance, diabetes mellitus, PCI of de novo lesion, PCI at a high volume center, and PCI at a suburban hospital were significant predictors of DES use. The availability of a second DES product did not influence the adoption patterns. Inhospital outcomes with DES were excellent. CONCLUSIONS: Access to DES was influenced by demographic, socioeconomic, and hospital characteristics. Further study is needed to determine if the availability of another DES platform or increased overall availability of DES impacts favorably on PCI practice patterns. |
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Authors:
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Sunil V Rao; Richard E Shaw; Ralph G Brindis; Lloyd W Klein; William S Weintraub; Ronald J Krone; Eric D Peterson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 152 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-31 Completed Date: 2006-09-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 321-6 Citation Subset: AIM; IM |
Affiliation:
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The Duke Clinical Research Institute, Durham, NC 27705, USA. sunil.rao@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angioplasty, Transluminal, Percutaneous Coronary* Cardiovascular Agents / administration & dosage* Coronary Disease / mortality, therapy* Coronary Restenosis / prevention & control Coronary Stenosis / therapy Drug Delivery Systems Female Hospital Mortality Humans Logistic Models Male Middle Aged Multivariate Analysis Myocardial Infarction / epidemiology Outcome Assessment (Health Care)* Registries Stents / economics, utilization* Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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