| Patterns of myocardial perfusion in humans evaluated with contrast-enhanced 320 multidetector computed tomography. | |
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MedLine Citation:
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PMID: 22143171 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Left ventricular (LV) myocardial contrast enhancement can be recorded using 320 multi detector computed tomography (MDCT). We aimed to (1) assess patterns of regional myocardial perfusion at rest and compare them with NH(3) positron emission tomography (PET) (2) and to assess the effect of intravenous adenosine infusion on regional myocardial perfusion. To evaluate myocardial perfusion patterns at rest, we scanned 14 healthy subjects with PET and 14 age and gender matched subjects with 320 MDCT. To evaluate the effect of adenosine stress on relative perfusion patterns 14 subjects with near-normal epicardial coronary arteries were studied at rest and during adenosine stress. Relative perfusion was assessed as attenuation density (AD) in 16 segments of the LV, and each segment was divided into 3 layers: endo-, mid- and epi-cardial. During rest the relative AD by MDCT was lower in the lateral wall compared with the remainder of the LV (P < 0.002). A similar pattern was found by PET-imaging. LV endocardial AD was higher than mid- and epicardial AD (P < 0.05). At rest the endocardial/epicardial ratio in the septum was 0.99 compared with 1.23 in non-septal segments (P < 0.001). During adenosine infusion transmural AD increased due to significant increases in the mid- and epicardium and the endocardial/epicardial ratio decreased by 18% in non-septal segments (from 1.23 to 1.05 P < 0.001). Relative perfusion at rest is lower in the lateral wall of the LV with both PET and MDCT compared to the remainder of the myocardium. During adenosine stress endocardial/epicardial ratio decrease significantly. |
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Authors:
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J Tobias Kühl; Jesper J Linde; Andreas Fuchs; Thomas S Kristensen; Henning Kelbæk; Richard T George; Jens D Hove; Klaus Fuglsang Kofoed |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: - ISSN: 1875-8312 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiology, 2012, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark, Tobiaskh@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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