Document Detail

Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state.
MedLine Citation:
PMID:  20553969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is growing recognition of the serious consequences of sarcopenia on the functionality and autonomy in old age. Recently, the age-related changes in several inflammatory mediators have been implicated in the pathogenesis of sarcopenia. The purposes of this systematic review were two-fold: (1) to describe the patterns of muscle strength loss with age in the general population, and (2) to quantify the loss of muscle strength in rheumatoid arthritis as representative for an underlying inflammatory state. Handgrip strength was used as a proxy for overall muscle strength.
RESULTS: Results from 114 studies (involving 90,520 subjects) and 71 studies (involving 10,529 subjects) were combined in a meta-analysis for the general and rheumatoid arthritis population respectively and standardized at an equal sex distribution. For the general population we showed that between the ages of 25 years and 95 years mean handgrip strength declined from 45.5 kg to 23.2 kg for males and from 27.1 kg to 12.8 kg for females. We noted a steeper handgrip strength decline after 50 years of age (rate of 0.37 kg/year). In the rheumatoid arthritis population handgrip strength was not associated with chronological age between the ages of 35 years and 65 years and was as low as 20.2 kg in male and 15.1 in female. Rheumatoid arthritis disease duration was inversely associated with handgrip strength.
CONCLUSIONS: This meta-analysis shows distinct patterns of age-related decrease of handgrip strength in the general population. Handgrip strength is strongly associated with the presence and duration of an inflammatory state as rheumatoid arthritis. The putative link between age-related inflammation and sarcopenia mandates further study as it represents a potential target for intervention to maintain functional independence in old age.
Karel G M Beenakker; Carolina H Ling; Carel G M Meskers; Anton J M de Craen; Theo Stijnen; Rudi G J Westendorp; Andrea B Maier
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-27
Journal Detail:
Title:  Ageing research reviews     Volume:  9     ISSN:  1872-9649     ISO Abbreviation:  Ageing Res. Rev.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128963     Medline TA:  Ageing Res Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Aged, 80 and over
Aging* / pathology,  physiology
Arthritis, Rheumatoid* / blood,  immunology,  physiopathology
Blood Sedimentation
C-Reactive Protein / analysis
Hand Strength* / physiology
Inflammation* / blood,  immunology
Interleukin-6 / blood,  immunology
Middle Aged
Muscle, Skeletal / pathology
Sarcopenia / blood,  immunology,  physiopathology
Tumor Necrosis Factor-alpha / blood,  immunology
Reg. No./Substance:
0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

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