Document Detail

Patterns of mobilization of copper and iron following myocardial ischemia: possible predictive criteria for tissue injury.
MedLine Citation:
PMID:  9405177     Owner:  NLM     Status:  MEDLINE    
Direct evidence for substantial iron and copper mobilization into the coronary flow immediately following prolonged, but not short, cardiac ischemia is presented. When small volumes of coronary flow fractions (CFFs) were serially collected upon reperfusion, after 25-60 min of ischemia, the copper and iron levels in the first CFF were 50-fold and 12- to 15-fold higher, respectively, than corresponding pre-ischemic values. The copper and iron levels after shorter periods (15-21 min) of ischemia were only about five-fold higher than the pre-ischemic values. This demonstrates that the resumption of coronary flow is accompanied by a burst of both metal ions. The levels of Cu/Fe in the CFFs correlated well with the loss of cardiac function following global ischemia of varying duration. After 18 min of ischemia, the residual cardiac function was less than 50%, and the damage was essentially reversible. After 25 min of ischemia, it exceeded 50% and was only partially reversible, while after 35 min, the damage exceeded 80%, and was mostly irreversible. The results are in accord with the hypothesis that copper and iron play causative roles in myocardial injury through mediation of hydroxyl radical production. Thus, the pattern of Cu/Fe mobilization from the tissue into the CFF can be used for the prediction of the severity of myocardial damage following ischemia, and could be developed into useful modalities for intervention in tissue injury.
E Berenshtein; B Mayer; C Goldberg; N Kitrossky; M Chevion
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  29     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-23     Completed Date:  1998-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3025-34     Citation Subset:  IM    
Copyright Information:
Copyright 1997 Academic Press Limited.
Department of Cellular Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel.
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MeSH Terms
Copper / metabolism*
Coronary Circulation / physiology*
Free Radicals
Hemodynamics / physiology
Iron / metabolism*
Myocardial Ischemia / metabolism*,  pathology
Myocardial Reperfusion Injury / diagnosis*,  physiopathology
Predictive Value of Tests
Rats, Sprague-Dawley
Reg. No./Substance:
0/Free Radicals; 7439-89-6/Iron; 7440-50-8/Copper

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