Document Detail


Patterns of meiotic variability of the (CAG)n repeat in the Huntington disease gene.
MedLine Citation:
PMID:  9219003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have collected 76 parent-offspring (CAG)n values in 60 French Huntington's disease (HD) pedigrees. The analysis of intergenerational alterations in CAG repeat length shows that there is a correlation between repeat instability and parental repeat length. Paternally inherited cases are characterized by a preferential trend towards an increase in range of repeat sizes in offspring of HD patients.
Authors:
G Lucotte; N Gérard; A Aouizérate; F Loirat; S Hazout
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genetic counseling (Geneva, Switzerland)     Volume:  8     ISSN:  1015-8146     ISO Abbreviation:  Genet. Couns.     Publication Date:  1997  
Date Detail:
Created Date:  1997-08-19     Completed Date:  1997-08-19     Revised Date:  2012-07-11    
Medline Journal Info:
Nlm Unique ID:  9015261     Medline TA:  Genet Couns     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  IM    
Affiliation:
Center of Neurogenetics, CHU of Reims, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
DNA / genetics
Female
Genetic Markers / genetics
Genetic Testing
Genetic Variation
Humans
Huntington Disease / diagnosis,  genetics*
Male
Meiosis / genetics*
Nerve Tissue Proteins / genetics*
Nuclear Proteins / genetics*
Repetitive Sequences, Nucleic Acid
Trinucleotide Repeats / genetics*
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/HTT protein, human; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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