Document Detail

Patterns of intestinal metaplasia in gastric biopsies. A comparison of different histochemical classifications.
MedLine Citation:
PMID:  1938465     Owner:  NLM     Status:  MEDLINE    
A total of 217 cases of gastric intestinal metaplasia (IM), out of 491 cases of consecutive multiple gastric biopsies, were examined using various histochemical methods. Three classifications were adopted (1) Jass and Filipe's (1979), (2) Segura and Montero's (1983), and (3) our own distinguishing two types of small intestine IM (incomplete and complete) and two types of colonic IM (incomplete and complete). Our classification revealed (1) a group of 'pure' IM cases (44%), (2) a group of 'combined' IM cases (15%), either small intestinal or colonic, expressing a maturating line, and (3) a conspicuous group of mixed 'mosaic' IM cases (41%) consisting of all possible combinations between the basic IM types. No significant correlations were found between each IM type and associated diseases (i.e. gastritis, stump gastritis, ulcer, adenoma and adenocarcinoma). However, a suggestive association between colonic IM and malignancy was observed. Our results confirmed the heterogeneity of IM and indicated two differentiation cell lines (ileal and colonic), thus providing additional evidence of impaired maturation and aberrant differentiation along various cell lines, supporting Leblond's (1976) unifying theory on the origin of intestinal epithelial cells.
P Baracchini; E Fulcheri; G Lapertosa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Histochemical journal     Volume:  23     ISSN:  0018-2214     ISO Abbreviation:  Histochem. J.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-12-10     Completed Date:  1991-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0163161     Medline TA:  Histochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Institute of Pathological Anatomy and Histology, University of Genoa, Italy.
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MeSH Terms
Gastric Mucosa / chemistry*
Histocytological Preparation Techniques
Intestinal Mucosa / chemistry*
Metaplasia / classification*,  pathology
Middle Aged
Mucins / analysis*
Reg. No./Substance:
0/Mucins; 0/Sialomucins; 0/sulfomucin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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