Document Detail

Patterns of in vitro behaviour characterizing cells of spontaneously metastasizing K2M rat sarcoma.
MedLine Citation:
PMID:  3500878     Owner:  NLM     Status:  MEDLINE    
Cells of K2M rat sarcoma and their descendants (RP, RPS) form tumours in syngeneic inbred rat strain LEW/CUB. Thirty to fifty per cent of tumour-bearing rats develop metastases, preferentially in the lung. In vitro, a quasi-stellate dynamic morphotype was characteristic of K2M cells and their descendants (RP, RPS): a highly changeable round or spindle-shaped or multipolar rather thick cell body with two or more protrusions of various length, often branching, and broadened at the tips, where vivid membrane activity was observed. Changeability of appearance and directionality of locomotion were stimulated in medium of pH 6.5. The enhanced expression of this morphotype correlated with the increased metastatic potential. In vitro, in poor, slightly acid medium metastasizing cells preserved the quasi-stellate dynamic morphotype and survived longer than non-metastasizing cells. It is likely that the observed combination of traits, viz. the quasi-stellate dynamic morphotype and, under unfavourable conditions, prolonged survival, increased migratory activity and decreased mitotic rate could be of significance in the metastatic cascade, mainly for the escape from the primary site.
P Veselý; A Chaloupková; P Urbanec; H Urbancová; L Bohác; E Krchnáková; F Franc; L Sprincl; K Vousden; R Moss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia biologica     Volume:  33     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-25     Completed Date:  1988-01-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  307-24     Citation Subset:  IM    
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
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MeSH Terms
Actins / analysis
Cell Line
Cell Movement
Cytoskeleton / ultrastructure
DNA, Neoplasm / genetics
Microscopy, Electron, Scanning
Neoplasm Metastasis
Rats, Inbred Lew
Sarcoma, Experimental / pathology*,  ultrastructure
Reg. No./Substance:
0/Actins; 0/DNA, Neoplasm

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