| Patterns of in vitro behaviour characterizing cells of spontaneously metastasizing K2M rat sarcoma. | |
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MedLine Citation:
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PMID: 3500878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells of K2M rat sarcoma and their descendants (RP, RPS) form tumours in syngeneic inbred rat strain LEW/CUB. Thirty to fifty per cent of tumour-bearing rats develop metastases, preferentially in the lung. In vitro, a quasi-stellate dynamic morphotype was characteristic of K2M cells and their descendants (RP, RPS): a highly changeable round or spindle-shaped or multipolar rather thick cell body with two or more protrusions of various length, often branching, and broadened at the tips, where vivid membrane activity was observed. Changeability of appearance and directionality of locomotion were stimulated in medium of pH 6.5. The enhanced expression of this morphotype correlated with the increased metastatic potential. In vitro, in poor, slightly acid medium metastasizing cells preserved the quasi-stellate dynamic morphotype and survived longer than non-metastasizing cells. It is likely that the observed combination of traits, viz. the quasi-stellate dynamic morphotype and, under unfavourable conditions, prolonged survival, increased migratory activity and decreased mitotic rate could be of significance in the metastatic cascade, mainly for the escape from the primary site. |
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Authors:
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P Veselý; A Chaloupková; P Urbanec; H Urbancová; L Bohác; E Krchnáková; F Franc; L Sprincl; K Vousden; R Moss |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Folia biologica Volume: 33 ISSN: 0015-5500 ISO Abbreviation: Folia Biol. (Praha) Publication Date: 1987 |
Date Detail:
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Created Date: 1988-01-25 Completed Date: 1988-01-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0234640 Medline TA: Folia Biol (Praha) Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 307-24 Citation Subset: IM |
Affiliation:
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Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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analysis Animals Cell Line Cell Movement Cytoskeleton / ultrastructure DNA, Neoplasm / genetics Mice Microscopy, Electron, Scanning Neoplasm Metastasis Rats Rats, Inbred Lew Sarcoma, Experimental / pathology*, ultrastructure Transfection |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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