Document Detail

Patterns of impairment in autobiographical memory in the degenerative dementias constrain models of memory.
MedLine Citation:
PMID:  16519908     Owner:  NLM     Status:  MEDLINE    
Detailed study of the autobiographical memory (ABM) impairments seen in different forms of degenerative dementia, in particular Alzheimer's disease (AD) and semantic dementia (SD) can inform neuropsychological models of memory. A modified ABM questionnaire which allowed more detailed analysis of episodic and semantic ABM was used to study the pattern of deficits in patients with minimal to mild Alzheimer's disease (AD) and in two patients with mild and moderate semantic dementia (SD). The questionnaire tested both cued and free recall. A group of healthy elderly was also tested. AD patients differed from controls in all measures. There was no clear temporal gradient for episodic ABM, but a modest gradient was observed for semantic ABM. The mild SD patient performed at control level for episodic ABM but showed a deficit within the range of the AD patients for semantic ABM except for the most recent life period. In contrast the moderate SD patient was impaired within the range of the AD patients for both episodic and semantic ABM. The evidence for differential impairment of episodic and semantic ABM retrieval in AD and SD is interpreted as supporting the multiple trace model of memory.
Adrian Ivanoiu; Janine M Cooper; Michael F Shanks; Annalena Venneri
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-07
Journal Detail:
Title:  Neuropsychologia     Volume:  44     ISSN:  0028-3932     ISO Abbreviation:  Neuropsychologia     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-09-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0020713     Medline TA:  Neuropsychologia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1936-55     Citation Subset:  IM    
Neurology Department and Neuropsychological Rehabilitation Unit, Saint Luc Hospital, University of Louvain, Brussels, Belgium.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / physiopathology
Analysis of Variance
Dementia / complications,  physiopathology*
Memory Disorders / classification*,  physiopathology*
Models, Psychological*
Neurodegenerative Diseases / physiopathology*
Neuropsychological Tests / statistics & numerical data
Grant Support
066349/Z/01/Z//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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