Document Detail

Patterns of glial cell activity in fronto-temporal dementia (lobar atrophy).
MedLine Citation:
PMID:  8866778     Owner:  NLM     Status:  MEDLINE    
Fronto-temporal dementia is a clinical syndrome with a number of pathological substrates, including frontal lobe degeneration, Pick's disease, and motor neuron disease with dementia; it also includes patients with a primary progressive language disorder. Twenty-four brains were examined, using immunohistochemistry for glial fibrillary acidic protein (GFAP) and ferritin. Five cases of fronto-temporal dementia with a Pick's disease type of histology showed marked cortical gliosis with striking microglial activity in both grey and white matter. In seven cases of frontal lobe degeneration, there was little gliosis and microglial activity was confined largely to the white matter; two of the seven cases of progressive language disorder showed similar changes to frontal lobe degeneration. Five cases of motor neuron disease with dementia showed both astrocytic and microglial activity within the white matter. We suggest that cases of fronto-temporal dementia due to Pick type histology may result from a process which primarily involves grey matter, whereas cases of frontal lobe degeneration might represent a disorder of white matter.
P N Cooper; C A Siddons; D M Mann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuropathology and applied neurobiology     Volume:  22     ISSN:  0305-1846     ISO Abbreviation:  Neuropathol. Appl. Neurobiol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7609829     Medline TA:  Neuropathol Appl Neurobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
Walton Centre, Liverpool, UK.
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MeSH Terms
Astrocytes / pathology
Dementia / pathology*
Frontal Lobe / pathology*
Motor Neuron Disease / pathology*
Neuroglia / pathology*
Temporal Lobe / pathology*

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