| Patterns of gene expression in peripheral blood mononuclear cells of rhesus macaques infected with SIVmac251 and exhibiting differential rates of disease progression. | |
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MedLine Citation:
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PMID: 12803996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the Affymetrix HuGeneFL GeneChip, the global expression patterns of genes in the peripheral blood mononuclear cells (PBMCs) of rhesus macaques, infected with SIVmac251 and exhibiting rapid, typical, or slow rates of disease progression, were examined. Assessments of the change in gene expression (fold change), the temporal coordination of gene expression (self-organizing map analysis), and the similarities and significant differences in gene expression across the groups were performed on samples taken before infection and 3 and 7 weeks postinfection. An upregulation of the p27 interferon-inducible gene and of genes associated with cellular activation and immune response was observed in all three groups. Rapidly progressing animals exhibited a modest number of genes with a change in expression of 3-fold or greater, typically progressing animals exhibited the greatest number, and slowly progressing animals exhibited the fewest. Self-organizing map cluster analysis indicated that rapidly progressing animals exhibited the least coordinated gene expression over the three study time points, typically progressing animals exhibited a moderate degree, and animals with slow progression exhibited the most coordinated gene expression. Mann-Whitney U analysis indicated that differences in gene expression were most pronounced between the rapidly and slowly progressing groups and least pronounced between the rapidly and typically progressing animals. These observations elucidate distinct features of gene expression in animals with different rates of disease progression. |
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Authors:
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Maryanne T Vahey; Martin E Nau; Michele Taubman; Jake Yalley-Ogunro; Peter Silvera; Mark G Lewis |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 19 ISSN: 0889-2229 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-06-13 Completed Date: 2003-08-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: United States |
Other Details:
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Languages: eng Pagination: 369-87 Citation Subset: IM; X |
Affiliation:
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Division of Retrovirology, Walter Reed Army Institute of Research, Washington, D.C. 20850, USA. mvahey@hivresearch.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Progression Gene Expression Profiling* Gene Expression Regulation Humans Leukocytes, Mononuclear / virology* Macaca mulatta Oligonucleotide Array Sequence Analysis Proteins / genetics, metabolism Simian Acquired Immunodeficiency Syndrome / physiopathology*, virology Simian immunodeficiency virus / pathogenicity*, physiology Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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N01-AI15481/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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