| Patterns of fractional amplitude of low-frequency oscillations in occipito-striato-thalamic regions of first-episode drug-naïve panic disorder. | |
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MedLine Citation:
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PMID: 22770722 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: This study was designed to investigate patterns of fractional amplitude of low-frequency fluctuations (fALFF, an indicator for the intensity of regional brain spontaneous activities) of patients with first-episode drug-naïve panic disorder (PD). METHODS: Thirty patients (17 females, 13 males, age: 47.70±10.69 years old) and twenty healthy controls (10 females, 10 males, age: 41.40±13.94 years old) received 3-Tesla resting-state functional magnetic resonance imaging (RFMRI) scanning and the rating of clinical scales. RFMRI data was processed and analyzed by the REST toolbox (resting-state functional MRI data analysis toolbox) to calculate fALFF. fALFF were compared between patients and controls to detect endophenotype of fALFF in patients with first-episode drug-naïve PD. RESULTS: We found decreased fALFF in right middle occipital gyrus [FDR (false discovery rate) corrected p<0.05, cluster >5 voxles, volume >135mm(3), T threshold: 6.1168, surface connected theory] and increased fALFF in right putamen and right ventral lateral nucleus of thalamus of patients (uncorrected p<0.00005, cluster >5 voxles, volume >135mm(3), T threshold: 4.5439, surface connected theory). fALFF of patients also showed a positive correlation with clinical rating scores of PD in right cuneus. CONCLUSIONS: Occipito-striato-thalamic dysfunction of fALFF might represent a kind of endophenotype biomarker of first-episode drug-naïve PD. |
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Authors:
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Chien-Han Lai; Yu-Te Wu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-5 |
Journal Detail:
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Title: Journal of affective disorders Volume: - ISSN: 1573-2517 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychiatry, Buddhist Tzu-Chi General Hospital, Taipei Branch, 289 Jianguo Road, Xindian City, Taipei County 231, Taipei, Taiwan; Brain Image Research Unit, Buddhist Tzu-Chi General Hospital, Taipei Branch, Taipei, Taiwan. |
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