Document Detail


Patterns of fos activation in rat raphe nuclei during feeding behavior.
MedLine Citation:
PMID:  18289515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To analyze the differential recruitment of the raphe nuclei during different phases of feeding behavior, rats were subjected to a food restriction schedule (food for 2 h/day, during 15 days). The animals were submitted to different feeding conditions, constituting the experimental groups: search for food (MFS), food ingestion (MFI), satiety (MFSa) and food restriction control (MFC). A baseline condition (BC) group was included as further control. The MFI and MFC groups, which presented greater autonomic and somatic activation, had more FOS-immunoreactive (FOS-IR) neurons. The MFI group presented more labeled cells in the linear (LRN) and dorsal (DRN) nuclei; the MFC group showed more labeling in the median (MRN), pontine (PRN), magnus (NRM) and obscurus (NRO) nuclei; and the MFSa group had more labeled cells in the pallidus (NRP). The BC exhibited the lowest number of reactive cells. The PRN presented the highest percentage of activation in the raphe while the DRN the lowest. Additional experiments revealed few double-labeled (FOS-IR+5-HT-IR) cells within the raphe nuclei in the MFI group, suggesting little serotonergic activation in the raphe during food ingestion. These findings suggest a differential recruitment of raphe nuclei during various phases of feeding behavior. Such findings may reflect changes in behavioral state (e.g., food-induced arousal versus sleep) that lead to greater motor activation, and consequently increased FOS expression. While these data are consistent with the idea that the raphe system acts as gain setter for autonomic and somatic activities, the functional complexity of the raphe is not completely understood.
Authors:
Luiz Fernando Takase; Maria Inês Nogueira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-26
Journal Detail:
Title:  Brain research     Volume:  1200     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  10-8     Citation Subset:  IM    
Affiliation:
Laboratory of Neurosciences, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Pathways / anatomy & histology,  metabolism
Biological Markers
Brain Mapping
Brain Stem / anatomy & histology,  metabolism*
Exploratory Behavior / physiology
Feeding Behavior / physiology*
Food Deprivation / physiology
Immunohistochemistry
Male
Motor Activity / physiology
Neurons / metabolism*
Proto-Oncogene Proteins c-fos / metabolism*
Raphe Nuclei / anatomy & histology,  metabolism*
Rats
Satiety Response / physiology
Serotonin / metabolism*
Up-Regulation / physiology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Proto-Oncogene Proteins c-fos; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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