Document Detail


Patterns of fast synaptic cholinergic activation of neurons in the celiac ganglia of cats.
MedLine Citation:
PMID:  2904769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fast nicotinic transmission was studied in vitro in neurons of isolated cat celiac ganglia. In the absence of nerve stimulation, neurons could be classified into three types: silent neurons, synaptically activated neurons, and spontaneously discharging neurons. In all three types, fast synaptic activation could be obtained in single neurons by stimulating with a single pulse both the splanchnic nerves or one of the peripheral nerves connected to the ganglia. During repetitive nerve stimulation, a gradual depression of the central and peripheral fast nicotinic activation occurred, which was not affected by phentolamine plus propranolol, domperidone, atropine, or naloxone. Repetitive nerve stimulation was followed by a long lasting discharge of excitatory postsynaptic potentials and action potentials that decreased gradually with time. This discharge, which was probably due to presynaptic or prejunctional facilitation of acetylcholine release from cholinergic terminals, was reduced by the application of phentolamine plus propranolol, domperidone, or atropine and increased with naloxone. The existence of the mechanisms described in this study reflects the complexity of the integrative processes at work in neurons of the cat celiac ganglia that involve fast synaptic cholinergic activation.
Authors:
J P Niel; N Clerc; Y Jule
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  255     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G759-66     Citation Subset:  IM    
Affiliation:
Département de Physiologie et Neurophysiologie, Unité Associée 205, Centre National de la Recherche Scientifique, Faculté des Sciences et Techniques, Saint-Jérôme, France.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Cats
Electric Stimulation
Ganglia, Sympathetic / physiology*
Hexamethonium
Hexamethonium Compounds / pharmacology
Membrane Potentials
Microelectrodes
Neurons / drug effects,  physiology*
Nicotine / pharmacology*
Reference Values
Splanchnic Nerves / drug effects,  physiology*
Synapses / physiology*
Synaptic Transmission*
Tubocurarine / pharmacology
Chemical
Reg. No./Substance:
0/Hexamethonium Compounds; 54-11-5/Nicotine; 57-95-4/Tubocurarine; 60-26-4/Hexamethonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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