| Patterns of cardiovascular pathology induced by diverse cardioactive drugs. | |
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MedLine Citation:
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PMID: 10720778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the beagle dog, exaggerated hypotension and tachycardia following administration of high doses of vasodilating antihypertensive drugs are associated with vascular injury and characteristic patterns of myocardial necrosis and haemorrhage. Cardiac and vascular inflammation and necrosis also occur in dogs in association with different functional changes including severe hypertension and the effects that follow treatment with high doses of vasoconstrictor and pressor drugs. More recently, cardioactive drugs of novel classes such as the endothelin antagonists have also been shown to produce vascular damage in the beagle dog but in the absence of ischaemic myocardial damage or significant haemodynamic alterations that typically follow administration of high doses of vasodilating antihypertensive or pressor drugs. This underlines the importance of a careful analysis of the patterns of cardiovascular pathology, their dose, temporal and spatial relationships in the context of functional changes. |
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Authors:
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P Greaves |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Toxicology letters Volume: 112-113 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-05-04 Completed Date: 2000-05-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 547-52 Citation Subset: IM |
Affiliation:
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Safety of Medicines, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Cheshire, UK. peter.greaves@alderley.zeneca.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteritis / chemically induced*, pathology Cardiovascular Agents / toxicity* Dogs Endothelins / antagonists & inhibitors Humans Hypertension / chemically induced Hypotension / chemically induced Muscle, Smooth, Vascular / drug effects*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Endothelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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