Document Detail

Patterns of alveolar fluid clearance in heart failure.
MedLine Citation:
PMID:  18579236     Owner:  NLM     Status:  MEDLINE    
Alveolar fluid clearance (AFC) is important in keeping the airspaces free of edema. This process is accomplished via passive and active transport of Na(+) across the alveolo-capillary barrier mostly by apical Na(+) channels and basolateral Na,K-ATPases, respectively. Patterns of alveolar fluid clearance were found to be decreased in acutely elevated left atrial pressures, possibly due to the inhibition of alveolar epithelial active sodium transport. On the other hand, chronic elevation of pulmonary capillary pressure, such as seen in experimental and clinical congestive heart failure, increases alveolar fluid clearance most likely secondary to upregulation of active sodium transport.
Irit Hochberg; Zaid Abassi; Zaher S Azzam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-06-24
Journal Detail:
Title:  International journal of cardiology     Volume:  130     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Internal Medicine B, Rambam: Human Health Care Campus, Haifa, Israel.
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MeSH Terms
Biological Transport / physiology
Bronchoalveolar Lavage Fluid*
Heart Failure / complications,  metabolism*,  pathology
Pulmonary Alveoli / metabolism*,  pathology
Pulmonary Edema / complications,  metabolism,  pathology

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