Document Detail

Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis.
MedLine Citation:
PMID:  19036473     Owner:  NLM     Status:  MEDLINE    
In diffusion tensor imaging (DTI), interpreting changes in terms of fractional anisotropy (FA) and mean diffusivity or axial (D(||)) and radial (D(⊥)) diffusivity can be ambiguous. The main objective of this study was to gain insight into the heterogeneity of age-related diffusion changes in human brain white matter by analyzing relationships between the diffusion measures in terms of concordance and discordance instead of evaluating them separately, which is difficult to interpret. Fifty-one cognitively normal subjects (22-79 years old) were studied with DTI at 4 Tesla. Age was associated with widespread concordant changes of decreased FA and increased MD but in some regions significant FA reductions occurred discordant to MD changes. Prominent age-related FA reductions were primarily related to greater radial (D(⊥)) than axial (D(||)) diffusivity changes, potentially reflecting processes of demyelination. In conclusion, concordant/discordant changes of DTI indices provide additional characterization of white matter alterations that accompany normal aging.
Yu Zhang; An-Tao Du; Satoru Hayasaka; Geon-Ho Jahng; Jennifer Hlavin; Wang Zhan; Michael W Weiner; Norbert Schuff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-11-25
Journal Detail:
Title:  Neurobiology of aging     Volume:  31     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-28     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1991-2001     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Aging / metabolism*,  physiology
Brain / metabolism,  radiography*
Diffusion Magnetic Resonance Imaging / instrumentation,  methods*
Image Interpretation, Computer-Assisted / methods
Middle Aged
Reference Values
Statistics, Nonparametric
Water / metabolism*
Young Adult
Grant Support
AG010897/AG/NIA NIH HHS; R01 AG010897/AG/NIA NIH HHS; R01 AG010897-23A2/AG/NIA NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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