Document Detail

Patterns of adherence to oral methadone: implications for prescribers.
MedLine Citation:
PMID:  17935928     Owner:  NLM     Status:  MEDLINE    
We investigated patterns of nonadherence to substitute treatment among patients attending an inner London community drug dependency unit and explored factors associated with nonadherence. We undertook 91 face-to-face confidential interviews with methadone-maintained patients attending community pharmacies. Thirty-eight patients (42%) had been either partial or poor adherers to their prescribed methadone regime in the past month. Multinomial logistic regression revealed that compared to full adherers, both poor adherers and partial adherers were more likely to be prescribed by unsupervised consumption. Poor adherers were also more likely to have less frequent pickups. There were seven types of nonadherent behavior detected, with dose splitting being the most prevalent (34%), followed by dose storage (28%) and missed pickups from the pharmacy (18%). We suggest that prescribers include an assessment of medication adherence at regular patient reviews as supervised consumption does not solve all adherence problems with methadone. New approaches to encouraging adherence, including a more systematic monitoring of adherence to improve the effectiveness of methadone programs, are needed.
Michael Haskew; Kim Wolff; John Dunn; Jenny Bearn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-01
Journal Detail:
Title:  Journal of substance abuse treatment     Volume:  35     ISSN:  1873-6483     ISO Abbreviation:  J Subst Abuse Treat     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-09-29     Revised Date:  2009-06-01    
Medline Journal Info:
Nlm Unique ID:  8500909     Medline TA:  J Subst Abuse Treat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-15     Citation Subset:  IM    
South Camden Drug Service, Camden and Islington Mental Health and Social Care NHS Trust, London, UK.
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MeSH Terms
Community Pharmacy Services
Data Collection
Logistic Models
Methadone / therapeutic use*
Middle Aged
Narcotics / therapeutic use*
Patient Compliance / psychology
Substance-Related Disorders / rehabilitation*
Treatment Refusal / psychology*
Reg. No./Substance:
0/Narcotics; 76-99-3/Methadone
Comment In:
J Subst Abuse Treat. 2009 Jun;36(4):463   [PMID:  19150204 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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