Document Detail


Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human.
MedLine Citation:
PMID:  19913997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Activity-dependent slowing of conduction velocity (ADS) differs between classes of human nociceptors. These differences likely reflect particular expression and use-dependent slow inactivation of axonal ion channels and other mechanisms governing axonal excitability. In this study, we compared ADS of porcine and human cutaneous C-fibers. Extracellular recordings were performed from peripheral nerves, using teased fiber technique in pigs and microneurography in humans. We assessed electrically-induced conduction changes and responsiveness to natural stimuli. In both species, the group of mechano-insensitive C-fibers showed the largest conduction slowing ( approximately 30%) upon electrical stimulation (2Hz for 3min). In addition, we found mechano-insensitive cold nociceptors in pig that slowed only minimally (<10% at 2Hz), and a similar slowing pattern was found in some human C-fibers. Mechano-sensitive afferents showed an intermediate conduction slowing upon 2Hz stimulation (pig: 14%, human 23%), whereas sympathetic efferent fibers in pig and human slowed only minimally (5% and 9%, respectively). In fiber classes with more pronounced slowing, conduction latencies recovered slower; i.e. mechano-insensitive afferents recovered the slowest, followed by mechano-sensitive afferents whereas cold nociceptors and sympathetic efferents recovered the fastest. We conclude that mechano-insensitive C-fiber nociceptors can be differentiated by their characteristic pattern of ADS which are alike in pig and human. Notably, cold nociceptors with a distinct ADS pattern were first detected in pig. Our results therefore suggest that the pig is a suitable model to study nociceptor class-specific changes of ADS.
Authors:
Otilia Obreja; Matthias Ringkamp; Barbara Namer; Elmar Forsch; Andreas Klusch; Roman Rukwied; Marlen Petersen; Martin Schmelz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-13
Journal Detail:
Title:  Pain     Volume:  148     ISSN:  1872-6623     ISO Abbreviation:  Pain     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  59-69     Citation Subset:  IM    
Copyright Information:
Copyright 2009 International Association for the Study of Pain. All rights reserved.
Affiliation:
Department of Anesthesiology Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Adult
Afferent Pathways / physiopathology
Animals
Biophysics / methods
Cold Temperature*
Electric Stimulation / methods
Female
Humans
Hyperalgesia / physiopathology
Male
Mechanoreceptors / physiology
Nerve Fibers, Unmyelinated / physiology*
Neural Conduction / physiology
Nociceptors / physiology*
Pain Threshold / physiology*
Swine / anatomy & histology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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