Document Detail


Patterns of pancreatic resection differ between patients with familial and sporadic pancreatic cancer.
MedLine Citation:
PMID:  21359597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well.
AIMS: This study aims to evaluate outcomes following resection in patients with familial PC.
METHODS: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients.
RESULTS: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52).
CONCLUSIONS: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.
Authors:
Joshua G Barton; Thomas Schnelldorfer; Christine M Lohse; William R Bamlet; Kari G Rabe; Gloria M Petersen; John H Donohue; Michael B Farnell; Michael L Kendrick; David M Nagorney; Kay M Reid Lombardo; Florencia G Que
Related Documents :
8671907 - Brief report: evaluation of the upper gastrointestinal tract in uraemic patients underg...
16935897 - Effect of dialysis membrane biocompatibility on polymorphonuclear granulocyte activity ...
2964417 - Teicoplanin in patients with chronic renal failure on dialysis: microbiological and pha...
18354377 - Hemodialysis of chronic kidney failure patients requiring ablative radioiodine therapy.
3872627 - Single-dose ceftriaxone versus multiple-dose trimethoprim-sulfamethoxazole in the treat...
3163697 - The expression of autoimmune polyglandular disease type i appears associated with sever...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-02-26
Journal Detail:
Title:  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract     Volume:  15     ISSN:  1873-4626     ISO Abbreviation:  J. Gastrointest. Surg.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-09-22     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9706084     Medline TA:  J Gastrointest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  836-42     Citation Subset:  IM    
Affiliation:
Division of GI and General Surgery, Mayo 12, 200 1st St. SW, Rochester, MN 55905, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biopsy
Female
Follow-Up Studies
Genetic Predisposition to Disease*
Humans
Male
Middle Aged
Neoplasm Staging
Pancreatectomy / methods*
Pancreatic Neoplasms / genetics,  pathology,  surgery*
Pedigree
Prospective Studies
Treatment Outcome
Grant Support
ID/Acronym/Agency:
P50 CA102701-09/CA/NCI NIH HHS; R01 CA097075-09/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Doppler-Guided Hemorrhoidal Artery Ligation: The Experience of a Single Institution.
Next Document:  Ezetimibe treatment lowers indicators of oxidative stress in hypercholesterolemic subjects with high...