Document Detail

Patterns of pancreatic resection differ between patients with familial and sporadic pancreatic cancer.
MedLine Citation:
PMID:  21359597     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well.
AIMS: This study aims to evaluate outcomes following resection in patients with familial PC.
METHODS: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients.
RESULTS: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52).
CONCLUSIONS: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.
Joshua G Barton; Thomas Schnelldorfer; Christine M Lohse; William R Bamlet; Kari G Rabe; Gloria M Petersen; John H Donohue; Michael B Farnell; Michael L Kendrick; David M Nagorney; Kay M Reid Lombardo; Florencia G Que
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-02-26
Journal Detail:
Title:  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract     Volume:  15     ISSN:  1873-4626     ISO Abbreviation:  J. Gastrointest. Surg.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-09-22     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9706084     Medline TA:  J Gastrointest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  836-42     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Follow-Up Studies
Genetic Predisposition to Disease*
Middle Aged
Neoplasm Staging
Pancreatectomy / methods*
Pancreatic Neoplasms / genetics,  pathology,  surgery*
Prospective Studies
Treatment Outcome
Grant Support
P50 CA102701/CA/NCI NIH HHS; P50 CA102701-09/CA/NCI NIH HHS; R01 CA097075/CA/NCI NIH HHS; R01 CA097075-09/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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