| Patterning of two-level topographic cues for observation of competitive guidance of cell alignment. | |
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MedLine Citation:
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PMID: 22839362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells display contact guidance when cultured on topographical cues. By combining standard photolithography, nanoimprint lithography, and soft lithography, we produced sophisticated patterns on two levels, including crossing microgrooves with different depth/spacing and microgrooves with superimposed submicrometer features. The results show that for narrowly spaced microgrooves, the contact guidance is more significant to the change of groove depth than to other geometry parameters. For crossing microgrooves, the shallow grooves take over the influence on cell alignment when the deeper grooves are well separated. Finally, the superimposed submicrometer features on the groove ridges decrease the efficiency of the contact guidance of microgrooves, due to increased adhesion of cells on patterned surfaces. |
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Authors:
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Xiongtu Zhou; Jie Hu; Junjun Li; Jian Shi; Yong Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-08-06 |
Journal Detail:
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Title: ACS applied materials & interfaces Volume: 4 ISSN: 1944-8252 ISO Abbreviation: ACS Appl Mater Interfaces Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-22 Completed Date: 2012-11-13 Revised Date: 2013-03-04 |
Medline Journal Info:
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Nlm Unique ID: 101504991 Medline TA: ACS Appl Mater Interfaces Country: United States |
Other Details:
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Languages: eng Pagination: 3888-92 Citation Subset: IM |
Affiliation:
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Ecole Normale Supérieure, CNRS-ENS-UPMC UMR 8640, 24 rue Lhomond, 75231 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry* Cell Adhesion Cell Culture Techniques / instrumentation*, methods* Dimethylpolysiloxanes / chemistry Equipment Design Materials Testing Mice Microscopy, Atomic Force / methods Microscopy, Electron, Scanning / methods Models, Statistical NIH 3T3 Cells Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Dimethylpolysiloxanes; 63148-62-9/baysilon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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