Document Detail

Patterning of two-level topographic cues for observation of competitive guidance of cell alignment.
MedLine Citation:
PMID:  22839362     Owner:  NLM     Status:  MEDLINE    
Cells display contact guidance when cultured on topographical cues. By combining standard photolithography, nanoimprint lithography, and soft lithography, we produced sophisticated patterns on two levels, including crossing microgrooves with different depth/spacing and microgrooves with superimposed submicrometer features. The results show that for narrowly spaced microgrooves, the contact guidance is more significant to the change of groove depth than to other geometry parameters. For crossing microgrooves, the shallow grooves take over the influence on cell alignment when the deeper grooves are well separated. Finally, the superimposed submicrometer features on the groove ridges decrease the efficiency of the contact guidance of microgrooves, due to increased adhesion of cells on patterned surfaces.
Xiongtu Zhou; Jie Hu; Junjun Li; Jian Shi; Yong Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-06
Journal Detail:
Title:  ACS applied materials & interfaces     Volume:  4     ISSN:  1944-8252     ISO Abbreviation:  ACS Appl Mater Interfaces     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-22     Completed Date:  2012-11-13     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  101504991     Medline TA:  ACS Appl Mater Interfaces     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3888-92     Citation Subset:  IM    
Ecole Normale Supérieure, CNRS-ENS-UPMC UMR 8640, 24 rue Lhomond, 75231 Paris, France.
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MeSH Terms
Biocompatible Materials / chemistry*
Cell Adhesion
Cell Culture Techniques / instrumentation*,  methods*
Dimethylpolysiloxanes / chemistry
Equipment Design
Materials Testing
Microscopy, Atomic Force / methods
Microscopy, Electron, Scanning / methods
Models, Statistical
NIH 3T3 Cells
Surface Properties
Reg. No./Substance:
0/Biocompatible Materials; 0/Dimethylpolysiloxanes; 63148-62-9/baysilon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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