Document Detail


Patterning skin by planar cell polarity: the multi-talented hair designer.
MedLine Citation:
PMID:  22229440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In mammals, the skin can form complex global and local patterns to meet diverse functional requirements in different parts of the body. To date, the fundamental principles that underlie skin patterning remain poorly understood because of the involvement of multiple interacting processes. Genes involved in the planar cell polarity (PCP) signalling pathway, which is capable of polarizing cells within the planar plane of an epithelium, can control the orientation and differentiation of hair follicles, underlining their involvement in skin pattern formation. Here, we summarize recent progress that has been made to understand the PCP signalling pathway and its function in mammalian skin, including its role in hair follicle morphogenesis, ciliogenesis and wound healing. We argue that dissecting PCP signalling in the context of hair follicle formation might reveal many as-yet-undiscovered functions for PCP in the development, homeostasis and regeneration of skin.
Authors:
Jiang Chen; Cheng-Ming Chuong
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Experimental dermatology     Volume:  21     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-10     Completed Date:  2012-06-18     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Dermatology, Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. jiang.chen@ucdenver.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / physiology*
Cell Differentiation / physiology
Cell Polarity / physiology*
Cilia / physiology
Epithelial Cells / cytology,  physiology
Hair Follicle / cytology*,  growth & development*,  metabolism
Homeostasis / physiology
Humans
Keratinocytes / cytology,  physiology
Regeneration / physiology
Signal Transduction / physiology
Translational Medical Research
Wound Healing / physiology
Grant Support
ID/Acronym/Agency:
AR042177/AR/NIAMS NIH HHS; AR047364/AR/NIAMS NIH HHS; AR060306/AR/NIAMS NIH HHS; AR061485/AR/NIAMS NIH HHS; R01 AR061485/AR/NIAMS NIH HHS; R01 AR061485-01/AR/NIAMS NIH HHS
Comments/Corrections

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