Document Detail


Pattern and time course of ventilation-perfusion inequality in exercise-induced asthma.
MedLine Citation:
PMID:  7065539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relation between exercise-induced airway obstruction and changes in the gas exchange function of the lung was studied in 6 subjects with asthma. Continuous distributions of ventilation perfusion (VA/Q) ratios and spirometry were measured before and at intervals after an exercise challenge that caused a greater than 20% decrease in FEV1 or in peak expiratory flow rate (PEFR). Before exercise, all subjects had unimodal VA/Q distributions that were broader than normal (mean log SD of blood flow, 0.54) and all developed wider distributions 15 to 28 min after the start of the 8-min exercise challenge (mean log SD of blood flow, 1.02). Two subjects developed bimodal VA/Q distributions, but all distributions returned to baseline configuration within 58 min, usually before FEV1 and PEFR had returned to baseline values. There was no relation between the decrease in FEV1 or PEFR and the degree of VA/Q inequality. Aerosolized salbutamol resulted in improved spirometry and further narrowing of the VA/Q distributions in 3 subjects tested.
Authors:
I H Young; P Corte; R E Schoeffel
Related Documents :
7102529 - The value of exercise in testing beta blockade and airway reactivity in asthmatic patie...
9484649 - A study of granulocyte respiratory burst in patients with allergic bronchial asthma.
9498939 - Beta2-adrenoceptor regulation and function in female asthmatic patients receiving the o...
21300299 - Effects of exercise training on high-mobility group box-1 levels after acute myocardial...
6142669 - Increased airway mucosal permeability of smokers. relationship to airway reactivity.
2009799 - Increased airways responsiveness in swine farmers.
10089139 - High expression of macrophage migration inhibitory factor in the synovial tissues of rh...
7658309 - Stimulation of neutrophil phagocytosis of aspergillus fumigatus conidia by interleukin-...
8520769 - The impact of exercise reconditioning on breathlessness in severe chronic airflow limit...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  125     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  304-11     Citation Subset:  AIM; IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Asthma / physiopathology*
Asthma, Exercise-Induced / blood,  physiopathology*
Forced Expiratory Volume
Humans
Male
Oxygen / blood
Peak Expiratory Flow Rate
Physical Exertion
Pulmonary Circulation
Time Factors
Ventilation-Perfusion Ratio*
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hypoxic ventilatory response decreases during sleep in normal men.
Next Document:  The effect of occupational exposure on pulmonary function: a longitudinal evaluation of fire fighter...