Document Detail

Pattern and time course of ventilation-perfusion inequality in exercise-induced asthma.
MedLine Citation:
PMID:  7065539     Owner:  NLM     Status:  MEDLINE    
The relation between exercise-induced airway obstruction and changes in the gas exchange function of the lung was studied in 6 subjects with asthma. Continuous distributions of ventilation perfusion (VA/Q) ratios and spirometry were measured before and at intervals after an exercise challenge that caused a greater than 20% decrease in FEV1 or in peak expiratory flow rate (PEFR). Before exercise, all subjects had unimodal VA/Q distributions that were broader than normal (mean log SD of blood flow, 0.54) and all developed wider distributions 15 to 28 min after the start of the 8-min exercise challenge (mean log SD of blood flow, 1.02). Two subjects developed bimodal VA/Q distributions, but all distributions returned to baseline configuration within 58 min, usually before FEV1 and PEFR had returned to baseline values. There was no relation between the decrease in FEV1 or PEFR and the degree of VA/Q inequality. Aerosolized salbutamol resulted in improved spirometry and further narrowing of the VA/Q distributions in 3 subjects tested.
I H Young; P Corte; R E Schoeffel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  125     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  304-11     Citation Subset:  AIM; IM; S    
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MeSH Terms
Asthma / physiopathology*
Asthma, Exercise-Induced / blood,  physiopathology*
Forced Expiratory Volume
Oxygen / blood
Peak Expiratory Flow Rate
Physical Exertion
Pulmonary Circulation
Time Factors
Ventilation-Perfusion Ratio*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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