| Pattern recognition at the maternal-fetal interface. | |
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MedLine Citation:
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PMID: 18716932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrauterine infections represent a significant threat to fetal well-being and pregnancy outcome. Recent studies suggest that non-immune cells of the maternal-fetal interface can actively recognize and respond to microbes through pattern recognition receptors, in order to control pathogens that may compromise the pregnancy. However, these same innate immune responses may inadvertently lead to excessive inflammation or apoptosis at the maternal-fetal interface. Thus, pattern recognition receptors may play a key role in infection-related pregnancy complications. This review discusses what is currently known about the role of Toll-like receptors and NOD-like receptors in controlling infections at the maternal-fetal interface, and what impact their function may have on pregnancy. |
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Authors:
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Vikki M Abrahams |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunological investigations Volume: 37 ISSN: 1532-4311 ISO Abbreviation: Immunol. Invest. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-21 Completed Date: 2008-11-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8504629 Medline TA: Immunol Invest Country: United States |
Other Details:
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Languages: eng Pagination: 427-47 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA. vikki.abrahams@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chlamydia Infections / etiology Female Humans Immunity, Innate / genetics, immunology Nod1 Signaling Adaptor Protein / immunology*, metabolism, therapeutic use Nod2 Signaling Adaptor Protein / immunology*, metabolism, therapeutic use Placenta / immunology*, metabolism, microbiology Pregnancy Pregnancy Complications, Infectious / diagnosis, genetics, immunology*, microbiology, prevention & control Signal Transduction / immunology Toll-Like Receptors / immunology*, metabolism, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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R01HD049446-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/NOD1 protein, human; 0/Nod1 Signaling Adaptor Protein; 0/Nod2 Signaling Adaptor Protein; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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