Document Detail

Pattern recognition at the maternal-fetal interface.
MedLine Citation:
PMID:  18716932     Owner:  NLM     Status:  MEDLINE    
Intrauterine infections represent a significant threat to fetal well-being and pregnancy outcome. Recent studies suggest that non-immune cells of the maternal-fetal interface can actively recognize and respond to microbes through pattern recognition receptors, in order to control pathogens that may compromise the pregnancy. However, these same innate immune responses may inadvertently lead to excessive inflammation or apoptosis at the maternal-fetal interface. Thus, pattern recognition receptors may play a key role in infection-related pregnancy complications. This review discusses what is currently known about the role of Toll-like receptors and NOD-like receptors in controlling infections at the maternal-fetal interface, and what impact their function may have on pregnancy.
Vikki M Abrahams
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunological investigations     Volume:  37     ISSN:  1532-4311     ISO Abbreviation:  Immunol. Invest.     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-11-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8504629     Medline TA:  Immunol Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-47     Citation Subset:  IM    
Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA.
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MeSH Terms
Chlamydia Infections / etiology
Immunity, Innate / genetics,  immunology
Nod1 Signaling Adaptor Protein / immunology*,  metabolism,  therapeutic use
Nod2 Signaling Adaptor Protein / immunology*,  metabolism,  therapeutic use
Placenta / immunology*,  metabolism,  microbiology
Pregnancy Complications, Infectious / diagnosis,  genetics,  immunology*,  microbiology,  prevention & control
Signal Transduction / immunology
Toll-Like Receptors / immunology*,  metabolism,  therapeutic use
Grant Support
Reg. No./Substance:
0/NOD1 protein, human; 0/Nod1 Signaling Adaptor Protein; 0/Nod2 Signaling Adaptor Protein; 0/Toll-Like Receptors

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