| Pattern of left ventricular filling in hypertrophic cardiomyopathy. Assessment by Doppler echocardiography and radionuclide angiography. | |
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MedLine Citation:
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PMID: 9740349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The left ventricle in hypertrophic cardiomyopathy is anatomically and functionally non-uniform. This study was undertaken to verify whether a heterogeneity in the pattern of diastolic filling can be detected along the left ventricular inflow tract in hypertrophic cardiomyopathy. METHODS AND RESULTS: Early (E) and late (A) diastolic velocities were recorded by Doppler echocardiography at mitral and at mid-ventricular level in 16 normal volunteers and 30 patients with hypertrophic cardiomyopathy. Patients with hypertrophic cardiomyopathy also underwent radionuclide angiography to assess left ventricular function. E wave decreased significantly in normal volunteers (80 +/- 15 to 60 +/- 14 cm x s(-1); P<0.001), but it increased in hypertrophic cardiomyopathy (76 +/- 22 to 87 +/- 28 cm x s(-1) P=0.04), whereas the A wave decreased similarly in both. By multivariate analysis, systolic asynchrony and the ejection fraction of left ventricular lateral wall were directly related to the pattern of early filling progression (r=0.656, F=9.467; P<0.002). Moreover, systolic asynchrony showed a univariate direct correlation with changes in E velocity (r=0.42; P=0.02). CONCLUSION: Many patients with hypertrophic cardiomyopathy have an acceleration of filling within the left ventricular inflow tract; this phenomenon is directly related to systolic asynchrony and ejection fraction of the left ventricular lateral wall, suggesting increased suction. |
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Authors:
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M A Losi; S Betocchi; F Manganelli; C Briguori; Q Ciampi; P Perrone-Filardi; L Pace; M Salvatore; M Chiariello |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European heart journal Volume: 19 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-11-24 Completed Date: 1998-11-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1261-7 Citation Subset: IM |
Affiliation:
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Institute of Internal Medicine, Cardiology and Cardiac Surgery, Federico II University School of Medicine, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cardiomyopathy, Hypertrophic / physiopathology*, radionuclide imaging, ultrasonography Child Diastole Echocardiography, Doppler* Female Humans Male Middle Aged Multivariate Analysis Radionuclide Angiography* Ventricular Dysfunction, Left* |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 1998 Aug;19(8):1125-7
[PMID:
9740334
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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