Document Detail

Pattern of left ventricular diastolic filling in chronic aortic regurgitation: a gated blood pool assessment.
MedLine Citation:
PMID:  3880999     Owner:  NLM     Status:  MEDLINE    
Limited information exists regarding the pattern of left ventricular diastolic filling in moderate to severe chronic aortic regurgitation (AR). The left ventricular diastolic filling curve derived from gated blood pool scans was evaluated in 24 normal subjects and 29 patients with AR. The peak filling rate (PFR), mean filling rate (MFR), peak ejection rate (PER), PFR/MFR, PFR/PER, and the time of the rapid filling period divided by the diastolic time were determined. PFR, MFR and PER were calculated as end-diastolic volumes per second (EDV/s). PFR was lower in the AR group than in the normal subjects (2.24 +/- 0.70 vs 3.09 +/- 0.71 EDV/s, p less than 0.001). Similarly, MFR was lower in the AR group (1.31 +/- 0.40 vs 1.63 +/- 0.29 EDV/s, p less than 0.01). PER was also reduced in the AR group. Both PFR/MFR and PFR/PER were reduced, while the ratio of rapid filling period to diastolic time was longer in the AR group than in normal subjects. Clinical evidence of congestive heart failure occurred in 8 patients in the AR group. Diastolic filling variables were not significantly different from the asymptomatic subgroup of patients with AR, but were abnormal when compared with those of normal subjects. In patients with AR, an abnormal pattern of diastolic filling was noted, consisting of a reduced PFR, MFR and PFR/ with a more linear pattern of filling (reduced PFR/MFR) during a longer rapid filling period.
S J Lavine; W P Follansbee; D P Shreiner; V Krishnaswami; P S Reddy; K S McKee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  55     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-01-29     Completed Date:  1985-01-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Valve Insufficiency / complications,  physiopathology*
Cardiac Output*
Chronic Disease
Heart Catheterization
Heart Failure / complications,  physiopathology
Heart Ventricles / physiopathology
Middle Aged
Myocardial Contraction*
Radioisotope Dilution Technique
Stroke Volume*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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