Document Detail


Pattern formation during vasculogenesis.
MedLine Citation:
PMID:  22692888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vasculogenesis, the assembly of the first vascular network, is an intriguing developmental process that yields the first functional organ system of the embryo. In addition to being a fundamental part of embryonic development, vasculogenic processes also have medical importance. To explain the organizational principles behind vascular patterning, we must understand how morphogenesis of tissue level structures can be controlled through cell behavior patterns that, in turn, are determined by biochemical signal transduction processes. Mathematical analyses and computer simulations can help conceptualize how to bridge organizational levels and thus help in evaluating hypotheses regarding the formation of vascular networks. Here, we discuss the ideas that have been proposed to explain the formation of the first vascular pattern: cell motility guided by extracellular matrix alignment (contact guidance), chemotaxis guided by paracrine and autocrine morphogens, and sprouting guided by cell-cell contacts.
Authors:
Andras Czirok; Charles D Little
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Birth defects research. Part C, Embryo today : reviews     Volume:  96     ISSN:  1542-9768     ISO Abbreviation:  Birth Defects Res. C Embryo Today     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-13     Completed Date:  2012-10-18     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101167665     Medline TA:  Birth Defects Res C Embryo Today     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-62     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA. aczirok@kumc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessels / anatomy & histology,  embryology*
Body Patterning / physiology*
Humans
Models, Biological*
Morphogenesis / physiology*
Neovascularization, Physiologic / physiology*
Grant Support
ID/Acronym/Agency:
HL068855/HL/NHLBI NIH HHS; HL087136/HL/NHLBI NIH HHS; R01 HL068855/HL/NHLBI NIH HHS; R01 HL087136/HL/NHLBI NIH HHS
Comments/Corrections

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