Document Detail

Pattern and determinants of ocular complications in leprosy patients in eastern Nepal.
MedLine Citation:
PMID:  21141014     Owner:  NLM     Status:  In-Process    
BACKGROUND: odular complications of leprosy can lead to blindness.
OBJECTIVE: to report the pattern and determinants of ocular complications in patients with leprosy from eastern Nepal.
METHODS: a cross-sectional study was carried out analyzing one hundred and eighty six patients of leprosy presenting between Jan 2002-Nov 2004. All the patients were categorized using WHO and Ridley and Jopling classification. After determining bacillary indices in all of them, a detailed ocular examination was carried out. Independent risk factors were determined for ocular involvement.
RESULTS: ocular complications were found in 30.65% of the leprosy patients; lagophthalmos (17.74%) was the most frequent followed by uveitis (8.60%). Most of the patients having visual loss had it due to corneal complications and none of the patients with uveitis had vision <6/18. The patients released from treatment (83.33%) and those currently on treatment (31.63%) had higher occurrence of complications. Risk factors for ocular involvement were higher bacillary index, longer disease duration (p-=0.031, RR=1.109, 95% CI=1.009-01.218) and decreased corneal sensation(p=0.001, RR=3.564; 95 % C I=2.014-6.306). Higher Schirmer values (p=0.012, RR=0.935, 95% CI=0.888-0.985) were found to be protective for ocular complications. STASTICS: SPSS ver 10.0 was used for data analysis. The P value of <0.05 was considered as significant.
CONCLUSIONS: the prevalence of complications is high in patients released from treatment for leprosy. Cornea-related complications are the most important cause of visual disability and blindness. Risk factors for ocular complications are higher bacillary index, longer disease duration and decreased corneal sensation.
S Javvadhi; H Das; S Agrawal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH     Volume:  1     ISSN:  2072-6805     ISO Abbreviation:  Nepal J Ophthalmol     Publication Date:    2009 Jan-Jun
Date Detail:
Created Date:  2010-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101505288     Medline TA:  Nepal J Ophthalmol     Country:  Nepal    
Other Details:
Languages:  eng     Pagination:  2-8     Citation Subset:  IM    
Departments of Ophthalmology, B P Koirala Institute of Health Sciences Dharan, Sunsari, Nepal.
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