Document Detail

Pattern of bone markers during pregnancy and their changes after delivery.
MedLine Citation:
PMID:  12566731     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether bone resorption markers change during pregnancy and lactation, and how they are correlated with human placental lactogen (hPL) and PRL. SUBJECTS: Young women before pregnancy, during pregnancy and during a 12-month post-delivery period (study group; n = 22); and age- and weight-matched normal cycling women (control group; n = 22) for a 20-month-period participated in the study. RESULTS: In the study group, women both during pregnancy (from the 8th up to the 38th week) and during a 6-month period of lactation, pyridinoline and deoxypyridinoline urinary levels were significantly higher than those of pre-pregnancy and control women. They returned to basal values at the 12th post-delivery month. During pregnancy there were early and late peak increases, at the 8th and 32nd week, respectively. At the 32nd, 34th, 36th and 38th week of pregnancy, pyridinoline and deoxypyridinoline urinary values were significantly correlated with hPL serum levels. CONCLUSIONS: During pregnancy the maternal bone resorption seems to vary critically at early and late stages. A complete reversal of these variations seems to occur after lactation. Further studies could evaluate if changes in placental function are capable of differently interfering with maternal bone resorption.
Anna Maria Paoletti; Marisa Orrù; Lucia Floris; Stefano Guerriero; Silvia Ajossa; Sandra Romagnino; Gian Benedetto Melis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  59     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  2003  
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Dipartimento Chirurgico Materno-Infantile e di Scienze delle Immagini, Università degli Studi di Cagliari, Italia.
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MeSH Terms
Amino Acids / urine
Biological Markers / blood,  urine
Bone Resorption / metabolism*
Delivery, Obstetric*
Lactation / metabolism
Placental Lactogen / blood
Postpartum Period / metabolism*
Pregnancy / metabolism*
Time Factors
Reg. No./Substance:
0/Amino Acids; 0/Biological Markers; 63800-01-1/pyridinoline; 90032-33-0/deoxypyridinoline; 9035-54-5/Placental Lactogen

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