Document Detail


Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy.
MedLine Citation:
PMID:  19323870     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A careful characterization of behavioral abnormalities in corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP) by reliable tools is still lacking. Literature data provided evidence of the usefulness of the Frontal Behavioral Inventory (FBI) to operationalize such disturbances, particularly in the frontotemporal lobar degeneration spectrum. The study aimed to evaluate the frequency and pattern of presentation of behavioral disturbances in a large sample of CBDS and PSP patients by FBI. METHODS: Sixty-eight CBDS and 57 PSP patients entered the study and underwent a standardized clinical and neuropsychological battery, and a structural brain imaging study. Behavioral disturbances were carefully analyzed by FBI. RESULTS: FBI scores were relatively low in both groups, being 6.7 +/- 8.2 and 5.6 +/- 6.1 in CBDS and PSP, respectively. Comparison of the behavioral profile between CBDS and PSP patients showed significant differences in apathy were more frequent in the latter (57.9% vs. 33.8%, P = 0.007), and the presence of alien hand/apraxia more frequent in the former group 39.7% vs. 10.5%, P = 0.001). Apathy correlated neither with age nor with motor disturbances as measured by UPDRS-III. Overall, the most frequent behavioral abnormalities present in both groups (>25%) were aspontaneity and logopenia. Aphasia (27.9%) and irritability (35.3%) were more frequent in CBDS compared to PSP, even if not statistically different. DISCUSSION: The present study has provided measures of behavioral disturbances in a population of PSP and CBDS patients, and further confirms the usefulness of the FBI scale.
Authors:
Barbara Borroni; Antonella Alberici; Chiara Agosti; Maura Cosseddu; Alessandro Padovani
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-03-27
Journal Detail:
Title:  International psychogeriatrics / IPA     Volume:  21     ISSN:  1041-6102     ISO Abbreviation:  Int Psychogeriatr     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007918     Medline TA:  Int Psychogeriatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Brescia, Italy. bborroni@inwind.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Behavioral Symptoms / diagnosis*,  psychology
Brain / pathology
Cognition Disorders / diagnosis*,  psychology
Dementia / diagnosis*,  pathology,  psychology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Personality Inventory
Questionnaires
Supranuclear Palsy, Progressive / diagnosis*,  pathology,  psychology
Syndrome
Tomography, Emission-Computed, Single-Photon

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