Document Detail

Pattern of ambulatory pharyngo-oesophageal motility and pH-metry in healthy volunteers.
MedLine Citation:
PMID:  11309051     Owner:  NLM     Status:  MEDLINE    
Oesophago-pharyngeal reflux is widely accepted as an aetiological factor in many laryngeal and lower respiratory tract diseases. This study aims to establish normal reference ranges for pharyngo-oesophageal pH and pressure. Twenty-five asymptomatic healthy volunteers underwent ambulatory pharyngo-oesophageal pressure and pH-metry. Acid exposure times were very low. Only one subject showed any evidence of oesophago-pharyngeal reflux during recumbency. Two distinct upper oesophageal sphincter pressure patterns were observed during recumbency-one with episodic dry swallows and moderate tonic pressures, the other with almost complete manometric quiescence. Negative results, i.e. the exclusion of abnormal cervical reflux, appear to be more achievable than quantifiable positive results, but this is not absolutely clear from our results. Categorisation of an individual as having abnormal upper pH-metry requires use of a synchronous pharyngeal probe. pH-metry is likely to be of value in establishing the role of reflux in relation to laryngeal or respiratory disease.
P D Yates; A Pryde; L Maher; R C Heading; J A Wilson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical otolaryngology and allied sciences     Volume:  26     ISSN:  0307-7772     ISO Abbreviation:  Clin Otolaryngol Allied Sci     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-19     Completed Date:  2001-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701793     Medline TA:  Clin Otolaryngol Allied Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  113-6     Citation Subset:  IM    
Department of Otolaryngology/Head & Neck Surgery, University of Newcastle, Newcastle-upon-Tyne, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ambulatory Care
Esophagogastric Junction / physiology
Gastric Acidity Determination
Gastroesophageal Reflux / diagnosis*
Hydrogen-Ion Concentration
Manometry / methods
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression of MUC1 and MUC2 glycoproteins in laryngeal cancer.
Next Document:  Middle cranial fossa approach for the repair of spontaneous cerebrospinal fluid otorrhoea using auto...