Document Detail

Pattern of airway response to allergen extract of Phleum pratensis in asthmatic patients during and outside the pollen season.
MedLine Citation:
PMID:  2193334     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the pattern of airway response to a specific bronchial provocative test (sBPT) with an extract of Phleum pratensis standardized in biological units (BU), we studied 27 patients with seasonal asthma due to grass pollen by means of allergologic evaluations, methacholine inhalation test and sBPT, outside the pollen season in all patients and, in 10 of them, also during the pollen season. We used a DeVilbiss 646 nebulizer with a dosimeter, giving increasing doses (0.01-2.5 BU) of the allergen solution and we monitored FEV1 to assess early (EAR) and late (LAR) airway responses. Outside the pollen season sBPT elicited an isolated EAR in 16 and a dual asthmatic response (DAR) in 11 patients. We observed no significant difference between EAR and DAR patients as regards the provocative dose causing a 15% fall in FEV1 (PD15FEV1) methacholine, EAR (expressed by PD15FEV1 allergen) or allergologic data. There was a significant relationship between PD15FEV1 allergen and PD15FEV1 methacholine (r = 0.43, p less than 0.05). The reproducibility of sBPT was assessed in 11 patients outside the pollen season. The correlation coefficients between the two tests were: r = 0.91, p less than 0.001 for the total delivered dose of allergen during sBPT; r = 0.79, p less than 0.01 for PD15FEV1 allergen; r = 0.95, p less than 0.001 for the maximum percent fall in FEV1 during LAR. Ten patients repeated all tests during the grass pollen season. PD15FEV1 methacholine and baseline FEV1 decreased significantly during the pollen season, but PD15FEV1 allergen did not change significantly during the season.(ABSTRACT TRUNCATED AT 250 WORDS)
P L Paggiaro; F L Dente; D Talini; E Bacci; B Vagaggini; C Giuntini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  57     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-01     Completed Date:  1990-08-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
2nd Medical Clinic, University of Pisa, Italy.
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MeSH Terms
Allergens / administration & dosage*
Asthma / physiopathology*
Bronchi / physiopathology*
Bronchial Provocation Tests*
Forced Expiratory Volume
Methacholine Chloride
Methacholine Compounds / diagnostic use
Reg. No./Substance:
0/Allergens; 0/Methacholine Compounds; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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