Document Detail

Pattern Electroretinograms During The Cold Pressor Test In Normals And Glaucoma Patients.
MedLine Citation:
PMID:  24576876     Owner:  NLM     Status:  Publisher    
PURPOSE: To examine the influence of the cold pressor test (CPT) on steady-state-pattern electroretinograms (PERG) in normal subjects and glaucoma patients.
METHODS: Steady state PERGs to 7.8 Hz pattern reversal stimuli were recorded in 63 subjects. Fifteen healthy control subjects, 14 patients with ocular hypertension (OHT) and 34 patients with open-angle glaucoma (20 normotensive (NTG) and 14 high tension glaucoma (HTG)) were examined. Steady State PERG amplitudes and latencies were analysed at baseline, during cold stimulus using a modified cold pressure test and during the subsequent recovery phase. Blood pressure and heart rate were simultaneously recorded in 10 normals and 11 glaucoma patients.
RESULTS: During the three test conditions (baseline, ice-water, warm-water) glaucoma patients (NTG and HTG) showed significantly reduced PERG amplitudes in comparison to control subjects (p<0.001) and to OHT patients (p<0.004). Patients with OHT displayed lower PERG amplitudes than control subjects (n.s., with consideration of Bonferroni). Only NTG patients showed a significant effect of the CPT on PERG amplitude (significant decrease during warm-water p=0.02). Latencies shortened significantly during warm-water period after cold stimulus in control subjects (p=0.05) and in NTG patients (p=0.02) with a non-significant trend of shortened latencies in the OHT (p=0.06) and HTG groups (p=0.3). Systolic and diastolic blood pressure increased during cold water (p < 0.001) and a decreased during warming up conditions (p < 0.001).
CONCLUSION: This study shows that a cold pressure test influences the PERG responses particularly in NTG.
Antonia La Mancusa; Folkert K Horn; Jan Kremers; Cord Rh Huchzermeyer; Michael Rudolph; Anselm G Juenemann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-27
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  -     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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