| Paton Prize Lecture Neural Circulatory Control during Exercise: Early Insights. | |
| | |
MedLine Citation:
|
PMID: 23261851 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract During exercise, the cardiovascular response is rapidly and appropriately matched to the intensity of the physical activity. The autonomic nervous system plays an important role in achieving this closely matched circulatory response by an increase in the sympathetic nerve activity to the heart, blood vessels, and adrenal medulla and a decrease in the parasympathetic nerve activity to the heart. Early insights into the mechanisms that controlled these cardiovascular changes during exercise were reported in the 19th century. At that time, two mechanisms were hypothesized to be responsible for these changes. In one mechanism, a signal arising in a central area of the brain causes a parallel activation of skeletal muscle contraction and of autonomic nervous system changes (now termed 'Central Command'). In the other mechanism, a signal arising in the contracting skeletal muscle causes a reflex activation of the autonomic nervous system changes (now termed 'Exercise Pressor Reflex'). Some important investigators involved in early studies include Johan Johansson, August Krogh, Johannes Lindhard, and Horace Smirk. Also, Frances Buchanan and Louis Fridericia should be recognized for their contributions. In more recent years, the important involvement of a third mechanism, the Arterial Baroreflex, has been elucidated. Since those early insights, experiments in both animals and humans have added important findings that strongly support these early hypotheses. |
| | |
Authors:
|
Jere H Mitchell |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-21 |
Journal Detail:
|
Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: Exp. Physiol. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Texas. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spinal Pathways Mediating Phrenic Activation during High Frequency Spinal Cord Stimulation.
Next Document: Proteomic analysis of rainbow trout (Oncorhynchus mykiss) intestinal epithelia: Physiological acclim...