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Patients with thymomas have an increased risk of developing additional malignancies: lack of immunological surveillance?
MedLine Citation:
PMID:  22276606     Owner:  NLM     Status:  In-Data-Review    
Granato F, Ambrosio M R, Spina D, Lazzi S, Rocca B J, Voltolini L, Bongiolatti S, Luzzi L, Gotti G, Leoncini L & Tosi P (2012) Histopathology 60, 270-277 Patients with thymomas have an increased risk of developing additional malignancies: lack of immunological surveillance? Aims:  To assess the risk, for patients with thymoma, of developing an additional malignancy (AM). Methods and results:  We studied 68 patients with thymomas. Based on the World Health Organization classification, the tumours were categorised as A, AB or B (B1, B2, B3) thymomas. Control populations comprised 114 patients with colorectal cancer, 108 patients with lymphoma and 123 patients with thyroid carcinoma. Patients with thymomas showed a higher risk of developing an AM (22 of 68 patients versus 11 of 114, eight of 108, and eight of 123 patients, respectively; P = 0.0002). The association between thymomas and AMs was related to the thymoma histotype, with B1, B2, B3 and AB tumours showing a higher risk of developing an AM than A thymomas (P = 0.0474). Conclusions:  Patients affected by thymomas showed a significantly higher risk of developing additional malignancies than those in the control groups, and cases that exhibited a predominantly cortical component were more likely to develop other neoplasms. This may be related to the functions of cortical thymic epithelial cells in providing for T lymphocyte maturation through interaction with major histocompatibility complexes.
Felice Granato; Maria R Ambrosio; Donatella Spina; Stefano Lazzi; Bruno J Rocca; Luca Voltolini; Stefano Bongiolatti; Luca Luzzi; Giuseppe Gotti; Lorenzo Leoncini; Piero Tosi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  60     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Limited.
Thoracic Surgery Unit, Department of Cardiothoracic and Vascular Surgery Anatomic Pathology Section, Department of Human Pathology and Oncology, Siena University Hospital, Siena, Italy.
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