Document Detail


Patients with systemic lupus erythematosus differ from healthy controls in their immunological response to acute psychological stress.
MedLine Citation:
PMID:  10600217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical observations suggest that psychological stress induces exacerbation of disease activity in patients with systemic lupus erythematosus (SLE). In order to determine whether SLE patients differ from healthy controls in their stress response, we analyzed heart rate, blood pressure, catecholamine concentration, lymphocyte subpopulations, natural killer (NK) cell activity, and expression of beta-adrenoceptors on PBMC before, immediately after, and 1 h after a public speaking task in 15 SLE patients and 15 healthy subjects. Both groups demonstrated similar psychological, cardiovascular, and neuroendocrine responses to acute stress. However, natural killer (CD16(+)/CD56(+)) cell numbers transiently increased after stress exposure, with significantly less pronounced changes in SLE patients. In addition, NK activity increased in healthy controls (n = 8) but not in SLE patients (n = 4) after acute stress. Furthermore, the number of beta(2)-adrenoceptors on PBMC significantly increased only in healthy subjects (n = 8) after stress but not in SLE patients (n = 7). These data indicate that SLE patients differ from healthy controls in stress-induced immune responses.
Authors:
C R Pawlak; R Jacobs; E Mikeska; S Ochsmann; M S Lombardi; A Kavelaars; C J Heijnen; R E Schmidt; M Schedlowski
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  13     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-12     Completed Date:  2000-01-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-302     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Affiliation:
Division of Medical Psychology, Hannover Medical School, Hannover, 30623, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Affect / physiology
Aged
Antibodies, Monoclonal / diagnostic use
Cell Survival / drug effects
Endocrine Glands / physiology
Female
Hemodynamics / physiology
Humans
Killer Cells, Natural / immunology,  physiology
Lupus Erythematosus, Systemic / immunology*
Lymphocyte Subsets / immunology
Lymphocytes / immunology,  physiology
Male
Middle Aged
Phenotype
Receptors, Adrenergic, alpha-2 / immunology,  metabolism
Stress, Psychological / immunology*
Tumor Necrosis Factor-alpha / biosynthesis
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Receptors, Adrenergic, alpha-2; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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