| Patients with systemic lupus erythematosus differ from healthy controls in their immunological response to acute psychological stress. | |
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MedLine Citation:
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PMID: 10600217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical observations suggest that psychological stress induces exacerbation of disease activity in patients with systemic lupus erythematosus (SLE). In order to determine whether SLE patients differ from healthy controls in their stress response, we analyzed heart rate, blood pressure, catecholamine concentration, lymphocyte subpopulations, natural killer (NK) cell activity, and expression of beta-adrenoceptors on PBMC before, immediately after, and 1 h after a public speaking task in 15 SLE patients and 15 healthy subjects. Both groups demonstrated similar psychological, cardiovascular, and neuroendocrine responses to acute stress. However, natural killer (CD16(+)/CD56(+)) cell numbers transiently increased after stress exposure, with significantly less pronounced changes in SLE patients. In addition, NK activity increased in healthy controls (n = 8) but not in SLE patients (n = 4) after acute stress. Furthermore, the number of beta(2)-adrenoceptors on PBMC significantly increased only in healthy subjects (n = 8) after stress but not in SLE patients (n = 7). These data indicate that SLE patients differ from healthy controls in stress-induced immune responses. |
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Authors:
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C R Pawlak; R Jacobs; E Mikeska; S Ochsmann; M S Lombardi; A Kavelaars; C J Heijnen; R E Schmidt; M Schedlowski |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 13 ISSN: 0889-1591 ISO Abbreviation: Brain Behav. Immun. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-01-12 Completed Date: 2000-01-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 287-302 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Academic Press. |
Affiliation:
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Division of Medical Psychology, Hannover Medical School, Hannover, 30623, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Affect / physiology Aged Antibodies, Monoclonal / diagnostic use Cell Survival / drug effects Endocrine Glands / physiology Female Hemodynamics / physiology Humans Killer Cells, Natural / immunology, physiology Lupus Erythematosus, Systemic / immunology* Lymphocyte Subsets / immunology Lymphocytes / immunology, physiology Male Middle Aged Phenotype Receptors, Adrenergic, alpha-2 / immunology, metabolism Stress, Psychological / immunology* Tumor Necrosis Factor-alpha / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Receptors, Adrenergic, alpha-2; 0/Tumor Necrosis Factor-alpha |
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