| Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis. | |
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MedLine Citation:
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PMID: 21057700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We have previously shown that patients with severe FXI deficiency have a low incidence of ischaemic stroke, but display the usual incidence of myocardial infarction. In the present study, we compared the incidence of deep-vein thrombosis (DVT) in 219 unrelated patients with severe FXI deficiency aged 20-94 to the incidence in a large population-based study. No cases of DVT were observed in the FXI-deficient cohort, a result that is significantly lower than the expected number (4.68) computed from the population-based study. The low incidence remains statistically significant when compared to three other population-based studies. These data suggest that severe FXI deficiency provides protection against DVT. |
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Authors:
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Ophira Salomon; David M Steinberg; Michal Zucker; David Varon; Ariella Zivelin; Uri Seligsohn |
Publication Detail:
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Type: Journal Article Date: 2010-11-05 |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 105 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-02 Completed Date: 2011-05-31 Revised Date: 2012-01-10 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 269-73 Citation Subset: IM |
Affiliation:
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The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer 52621, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Case-Control Studies Factor XI Deficiency / epidemiology*, genetics Female Genetic Predisposition to Disease Hemostasis / genetics* Humans Incidence Israel / epidemiology Male Middle Aged Phenotype Polymorphism, Genetic Risk Assessment Risk Factors Severity of Illness Index Venous Thrombosis / epidemiology*, prevention & control Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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