Document Detail

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis.
MedLine Citation:
PMID:  21057700     Owner:  NLM     Status:  MEDLINE    
Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We have previously shown that patients with severe FXI deficiency have a low incidence of ischaemic stroke, but display the usual incidence of myocardial infarction. In the present study, we compared the incidence of deep-vein thrombosis (DVT) in 219 unrelated patients with severe FXI deficiency aged 20-94 to the incidence in a large population-based study. No cases of DVT were observed in the FXI-deficient cohort, a result that is significantly lower than the expected number (4.68) computed from the population-based study. The low incidence remains statistically significant when compared to three other population-based studies. These data suggest that severe FXI deficiency provides protection against DVT.
Ophira Salomon; David M Steinberg; Michal Zucker; David Varon; Ariella Zivelin; Uri Seligsohn
Publication Detail:
Type:  Journal Article     Date:  2010-11-05
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  105     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-05-31     Revised Date:  2012-01-10    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  IM    
The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer 52621, Israel.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Factor XI Deficiency / epidemiology*,  genetics
Genetic Predisposition to Disease
Hemostasis / genetics*
Israel / epidemiology
Middle Aged
Polymorphism, Genetic
Risk Assessment
Risk Factors
Severity of Illness Index
Venous Thrombosis / epidemiology*,  prevention & control
Young Adult

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