| Patients with rest-tremor and scans with ipsilateral dopaminergic deficit. | |
| | |
MedLine Citation:
|
PMID: 23196338 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Dopamine transporter imaging is typically abnormal in Parkinson's disease and shows reduced striatal uptake, which is typically greater contralateral to the clinically more affected side. However, tremor-dominant Parkinson's disease patients may have significantly lower uptake in the striatum ipsilateral to the rest-tremor compared to akinetic-rigid PD patients, implying a possible role of an ipsilateral deficit in the generation of rest-tremor.We report here three patients with rest-tremor and the unexpected finding of an ipsilateral presynaptic dopaminergic deficit with normal uptake contralateral to the rest-tremor in dopamine transporter imaging. We divided them in two groups, with and without a corresponding structural lesion in brain imaging. These data may suggest a role of ipsilateral dopaminergic deficit in the generation of rest-tremor. An explanation of these findings could be damage of crossed dopaminergic fibres from the substantia nigra to thalamus, which can cause motor impairment ipsilateral to dopamine depletion experimentally. This is speculative but there is no doubt that these cases exist and we encourage others to report similar cases, as this may assist in the better understanding of the yet unknown pathophysiology of rest-tremor. |
| | |
Authors:
|
Maria Aguirregomozcorta; Maria Stamelou; Angelo Antonini; Petra Schwingenschuh; Liz Prvulovich; Mark J Edwards; John C Dickson; Kailash P Bhatia |
Related Documents
:
|
23188988 - Unilateral contiguous two level thoracic ossified hypertrophied facet joints with compr... 20195068 - Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease... 3615888 - Degenerative lumbar disk disease: pitfalls and usefulness of mr imaging in detection of... 23295468 - Improving diagnosis of tumor-induced osteomalacia with gallium-68 dotatate pet/ct. 15262548 - Magnetic resonance imaging of the achilles tendon using ultrashort te (ute) pulse seque... 16023548 - Differences between attention-deficit disorder with and without hyperactivity: a 1h-mag... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-30 |
Journal Detail:
|
Title: Journal of neurology Volume: - ISSN: 1432-1459 ISO Abbreviation: J. Neurol. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0423161 Medline TA: J Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical use of frataxin measurement in a patient with a novel deletion in the FXN gene.
Next Document: The Prehospital Burden of Disease due to Trauma in KwaZulu-Natal: The Need for Afrocentric Trauma Sy...