Document Detail

Patients with rest-tremor and scans with ipsilateral dopaminergic deficit.
MedLine Citation:
PMID:  23196338     Owner:  NLM     Status:  MEDLINE    
Dopamine transporter imaging is typically abnormal in Parkinson's disease and shows reduced striatal uptake, which is typically greater contralateral to the clinically more affected side. However, tremor-dominant Parkinson's disease patients may have significantly lower uptake in the striatum ipsilateral to the rest-tremor compared to akinetic-rigid PD patients, implying a possible role of an ipsilateral deficit in the generation of rest-tremor.We report here three patients with rest-tremor and the unexpected finding of an ipsilateral presynaptic dopaminergic deficit with normal uptake contralateral to the rest-tremor in dopamine transporter imaging. We divided them in two groups, with and without a corresponding structural lesion in brain imaging. These data may suggest a role of ipsilateral dopaminergic deficit in the generation of rest-tremor. An explanation of these findings could be damage of crossed dopaminergic fibres from the substantia nigra to thalamus, which can cause motor impairment ipsilateral to dopamine depletion experimentally. This is speculative but there is no doubt that these cases exist and we encourage others to report similar cases, as this may assist in the better understanding of the yet unknown pathophysiology of rest-tremor.
Maria Aguirregomozcorta; Maria Stamelou; Angelo Antonini; Petra Schwingenschuh; Liz Prvulovich; Mark J Edwards; John C Dickson; Kailash P Bhatia
Related Documents :
24066198 - Role of cardiac mri in the assessment of nonischemic cardiomyopathies.
25016128 - Structural and microstructural brain changes predict impairment in daily functioning.
24390938 - Whole-body mri assessment of disease activity and structural damage in rheumatoid arthr...
23480738 - Advances in the diagnosis of leukoencephalopathies.
21606258 - Adrenocortical carcinoma: the range of appearances on ct and mri.
21997548 - Mri: the new reference standard in quantifying hepatic steatosis?
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-30
Journal Detail:
Title:  Journal of neurology     Volume:  260     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-09-26     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1132-5     Citation Subset:  IM    
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / pathology*,  radionuclide imaging
Dopamine / deficiency*
Functional Laterality / physiology*
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Tremor / metabolism*,  radionuclide imaging
Tropanes / diagnostic use
Young Adult
Reg. No./Substance:
0/Tropanes; 155797-99-2/2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical use of frataxin measurement in a patient with a novel deletion in the FXN gene.
Next Document:  The Prehospital Burden of Disease due to Trauma in KwaZulu-Natal: The Need for Afrocentric Trauma Sy...