Document Detail


Patients with rest-tremor and scans with ipsilateral dopaminergic deficit.
MedLine Citation:
PMID:  23196338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dopamine transporter imaging is typically abnormal in Parkinson's disease and shows reduced striatal uptake, which is typically greater contralateral to the clinically more affected side. However, tremor-dominant Parkinson's disease patients may have significantly lower uptake in the striatum ipsilateral to the rest-tremor compared to akinetic-rigid PD patients, implying a possible role of an ipsilateral deficit in the generation of rest-tremor.We report here three patients with rest-tremor and the unexpected finding of an ipsilateral presynaptic dopaminergic deficit with normal uptake contralateral to the rest-tremor in dopamine transporter imaging. We divided them in two groups, with and without a corresponding structural lesion in brain imaging. These data may suggest a role of ipsilateral dopaminergic deficit in the generation of rest-tremor. An explanation of these findings could be damage of crossed dopaminergic fibres from the substantia nigra to thalamus, which can cause motor impairment ipsilateral to dopamine depletion experimentally. This is speculative but there is no doubt that these cases exist and we encourage others to report similar cases, as this may assist in the better understanding of the yet unknown pathophysiology of rest-tremor.
Authors:
Maria Aguirregomozcorta; Maria Stamelou; Angelo Antonini; Petra Schwingenschuh; Liz Prvulovich; Mark J Edwards; John C Dickson; Kailash P Bhatia
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-30
Journal Detail:
Title:  Journal of neurology     Volume:  260     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-09-26     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1132-5     Citation Subset:  IM    
Affiliation:
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain / pathology*,  radionuclide imaging
Dopamine / deficiency*
Female
Functional Laterality / physiology*
Humans
Male
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Tremor / metabolism*,  radionuclide imaging
Tropanes / diagnostic use
Young Adult
Chemical
Reg. No./Substance:
0/Tropanes; 155797-99-2/2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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