| Patients with persistent atrial fibrillation taking oral verapamil exhibit a lower atrial frequency on the ECG. | |
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MedLine Citation:
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PMID: 12049679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: While there is agreement that verapamil attenuates the AF- induced refractory period shortening when given before AF induction, controversy exists regarding its effects when given after the onset of persistent AF. This study aimed to compare atrial fibrillatory frequency obtained from the surface ECG in patients with persistent atrial fibrillation (AF) with oral verapamil treatment to those without this treatment. METHODS AND RESULTS: Surface ECG recordings were performed in 57 patients (34 male, 23 female, mean age 59 +/- 11 years) with persistent AF (> 7 days). The frequency content of the fibrillatory baseline was quantified using digital signal processing (filtering, QRST complex averaging and subtraction, Fourier transformation). In 27 patients with verapamil treatment (120 or 240 mg/day for at least 7 days) mean fibrillatory frequency measured 6.4 +/- 0.2 Hz, compared to 7.0 +/- 0.4 Hz (P = 0.012) in 30 patients without verapamil. In a subset of 20 randomly selected patients (10 with, 10 without verapamil treatment) a 24-hour Holter ECG recording was performed and fibrillatory frequency determined at 4 PM, 10 PM, 4 AM, and 10 AM. While there was a significant frequency reduction in the verapamil treated patients at night (P = 0.011), it remained constant over time in the other patients. CONCLUSION: In patients with persistent AF, fibrillatory frequency assessed by spectral analysis of the surface ECG is lower in patients taking verapamil. |
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Authors:
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Andreas Bollmann; Kai Sonne; Hans-Dieter Esperer; Ines Toepffer; Helmut U Klein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 7 ISSN: 1082-720X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-06-06 Completed Date: 2002-07-30 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 92-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Hospital Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. andreas.bollmann@medizin.uni-magdeburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Anti-Arrhythmia Agents / therapeutic use* Atrial Fibrillation / drug therapy*, physiopathology* Circadian Rhythm Electrocardiography, Ambulatory* Female Heart Atria / physiopathology Heart Conduction System / drug effects Humans Male Middle Aged Signal Processing, Computer-Assisted Verapamil / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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