Document Detail

Patients with persistent atrial fibrillation taking oral verapamil exhibit a lower atrial frequency on the ECG.
MedLine Citation:
PMID:  12049679     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: While there is agreement that verapamil attenuates the AF- induced refractory period shortening when given before AF induction, controversy exists regarding its effects when given after the onset of persistent AF. This study aimed to compare atrial fibrillatory frequency obtained from the surface ECG in patients with persistent atrial fibrillation (AF) with oral verapamil treatment to those without this treatment. METHODS AND RESULTS: Surface ECG recordings were performed in 57 patients (34 male, 23 female, mean age 59 +/- 11 years) with persistent AF (> 7 days). The frequency content of the fibrillatory baseline was quantified using digital signal processing (filtering, QRST complex averaging and subtraction, Fourier transformation). In 27 patients with verapamil treatment (120 or 240 mg/day for at least 7 days) mean fibrillatory frequency measured 6.4 +/- 0.2 Hz, compared to 7.0 +/- 0.4 Hz (P = 0.012) in 30 patients without verapamil. In a subset of 20 randomly selected patients (10 with, 10 without verapamil treatment) a 24-hour Holter ECG recording was performed and fibrillatory frequency determined at 4 PM, 10 PM, 4 AM, and 10 AM. While there was a significant frequency reduction in the verapamil treated patients at night (P = 0.011), it remained constant over time in the other patients. CONCLUSION: In patients with persistent AF, fibrillatory frequency assessed by spectral analysis of the surface ECG is lower in patients taking verapamil.
Andreas Bollmann; Kai Sonne; Hans-Dieter Esperer; Ines Toepffer; Helmut U Klein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  7     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-06-06     Completed Date:  2002-07-30     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-7     Citation Subset:  IM    
Department of Cardiology, University Hospital Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
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MeSH Terms
Administration, Oral
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / drug therapy*,  physiopathology*
Circadian Rhythm
Electrocardiography, Ambulatory*
Heart Atria / physiopathology
Heart Conduction System / drug effects
Middle Aged
Signal Processing, Computer-Assisted
Verapamil / therapeutic use*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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