Document Detail


Patients with obstructive sleep apnea have an abnormal peripheral vascular response to hypoxia.
MedLine Citation:
PMID:  10484589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with obstructive sleep apnea (OSA) have been reported to have an augmented pressor response to hypoxic rebreathing. To assess the contribution of the peripheral vasculature to this hemodynamic response, we measured heart rate, mean arterial pressure (MAP), and forearm blood flow by venous occlusion plethysmography in 13 patients with OSA and in 6 nonapneic control subjects at arterial oxygen saturations (Sa(O(2))) of 90, 85, and 80% during progressive isocapnic hypoxia. Measurements were also performed during recovery from 5 min of forearm ischemia induced with cuff occlusion. MAP increased similarly in both groups during hypoxia (mean increase at 80% Sa(O(2)): OSA patients, 9 +/- 11 mmHg; controls, 12 +/- 7 mmHg). Forearm vascular resistance, calculated from forearm blood flow and MAP, decreased in controls (mean change -37 +/- 19% at Sa(O(2)) 80%) but not in patients (mean change -4 +/- 16% at 80% Sa(O(2))). Both groups decreased forearm vascular resistance similarly after forearm ischemia (maximum change from baseline -85%). We conclude that OSA patients have an abnormal peripheral vascular response to isocapnic hypoxia.
Authors:
S Remsburg; S H Launois; J W Weiss
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  87     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-14     Completed Date:  1999-10-14     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1148-53     Citation Subset:  IM; S    
Affiliation:
Charles A. Dana Institute and the Harvard-Thorndike Laboratory of Beth Israel Deaconess Medical Center, Boston 02215, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anoxia / physiopathology*
Blood Pressure / physiology
Female
Forearm / blood supply
Heart Rate / physiology
Humans
Male
Middle Aged
Regional Blood Flow / physiology
Respiratory Mechanics / physiology
Sleep Apnea Syndromes / physiopathology*
Vascular Resistance / physiology*
Grant Support
ID/Acronym/Agency:
HL-46951/HL/NHLBI NIH HHS; MO1-RR01032/RR/NCRR NIH HHS

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