| Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei. | |
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MedLine Citation:
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PMID: 15801987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacological efficacy of serotonergic-acting drugs suggest that patients with obsessive-compulsive disorder (OCD) may have alterations in their cerebral serotonergic (5-HT) receptor system, and previous neuroimaging studies of OCD patients have shown abnormalities in several fronto-subcortical regions. In this study we investigated cerebral 5-HT(2A) receptor binding in 15 untreated OCD patients and in 15 age- and gender-matched healthy volunteers by magnetic resonance imaging and [(18)F]altanserin positron emission tomography (PET). Eleven of the patients were rescanned with PET after receiving treatment with a selective serotonin reuptake inhibitor (SSRI). The distribution volumes of specific tracer binding (DV(3)') were calculated for 12 brain regions, and comparisons were made between: (1) healthy volunteers vs. untreated OCD patients, (2) healthy volunteers vs. treated OCD patients, and (3) OCD patients before and during treatment. When comparing the distribution volume for specific fronto-subcortical brain regions, significantly higher values were recorded in the caudate nuclei in OCD patients (DV(3)': 0.24+/-0.14) compared to the healthy control group (DV(3)': 0.15+/-0.13) (p<0.05, Wilcoxon matched-pairs test). This difference between groups was not present after treatment with SSRIs. There was no correlation between the severity of OCD symptoms and 5-HT(2A )receptor binding. An increase in 5-HT(2A) receptor binding is found in the caudate nuclei of untreated patients with OCD. The up-regulation in 5-HT(2A) receptors might be compensatory for a lack of serotonin in the feedback loop between the thalamus and orbito-frontal cortex, the caudate nuclei, and the globus pallidus. |
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Authors:
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Karen H Adams; Elsebeth S Hansen; Lars H Pinborg; Steen G Hasselbalch; Claus Svarer; Søren Holm; Tom G Bolwig; Gitte M Knudsen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-04-01 |
Journal Detail:
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Title: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) Volume: 8 ISSN: 1461-1457 ISO Abbreviation: Int. J. Neuropsychopharmacol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-06-24 Completed Date: 2006-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815893 Medline TA: Int J Neuropsychopharmacol Country: England |
Other Details:
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Languages: eng Pagination: 391-401 Citation Subset: IM |
Affiliation:
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Neurobiology Research Unit (NRU), University Hospital of Copenhagen, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antidepressive Agents / pharmacology, therapeutic use Brain Mapping Caudate Nucleus / drug effects, metabolism*, pathology Female Fluorine Radioisotopes / pharmacokinetics Humans Ketanserin / analogs & derivatives, pharmacokinetics Magnetic Resonance Imaging / methods Male Middle Aged Obsessive-Compulsive Disorder / drug therapy*, metabolism*, pathology Positron-Emission Tomography / methods Protein Binding / drug effects, physiology Receptor, Serotonin, 5-HT2A / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Fluorine Radioisotopes; 0/Receptor, Serotonin, 5-HT2A; 74050-98-9/Ketanserin; 76330-71-7/altanserin |
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