Document Detail

Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case series.
MedLine Citation:
PMID:  19878938     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the symptoms and outcomes of ovarian stimulation in patients with a history of hyperemesis gravidarum.
DESIGN: Retrospective case series.
SETTING: Research laboratory of a university hospital.
PATIENT(S): Participants in an ongoing study on hyperemesis gravidarum that reported ovarian stimulation for gestational surrogacy.
INTERVENTION(S): Review of medical records.
MAIN OUTCOME MEASURE(S): Pregnancy history, symptoms, estradiol level and mature oocyte number in cases, and nausea and vomiting level reported in surrogate.
RESULT(S): Three cases in their early thirties with a history of hyperemesis gravidarum presented with severe nausea and vomiting during ovarian stimulation and ovarian hyperstimulation syndrome. Gestational carriers reported normal nausea and vomiting of pregnancy.
CONCLUSION(S): This series provides lessons for in vitro fertilization for cases with a history of hyperemesis gravidarum and their gestational carriers as well as insight into the cause of hyperemesis gravidarum and its potential role in fertility. A link between hyperemesis gravidarum and an evolutionary advantage of increased fertility suggests a novel theory to explain the selection for nausea and vomiting in pregnancy.
Marlena S Fejzo; Roberto Romero; T Murphy Goodwin
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Intramural     Date:  2009-10-29
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-02-22     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267.e9-11     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. All rights reserved.
Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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MeSH Terms
Fertilization in Vitro
Genetic Predisposition to Disease
Hyperemesis Gravidarum / genetics,  physiopathology*,  therapy
Nausea / etiology
Ovarian Hyperstimulation Syndrome / etiology*,  physiopathology
Ovulation Induction / adverse effects*
Parenteral Nutrition, Total
Severity of Illness Index
Surrogate Mothers*
Vomiting / etiology
Grant Support

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