Document Detail


Patients with generalised epilepsy have a higher white blood cell count than patients with focal epilepsy.
MedLine Citation:
PMID:  22433317     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background. Immunological alterations have been noted following seizures in the acute period, however little is known about the effect of type and severity of epilepsy on leukocyte count in the absence of seizures. Methods. We performed a retrospective chart review of adult epilepsy patients presenting for evaluation over a four-month period. Demographics, epilepsy type and characteristics, number and type of antiepileptic drugs, as well as medical co-morbidities were noted. Results. A total of 241 patients fulfilled study criteria. Variables correlating with leukocyte count were identified using univariate analysis. Based on multivariate analysis, only the correlation with type of epilepsy and use of more than two antiepileptic drugs remained statistically significant. Patients with generalised epilepsy had a higher leukocyte count (7.21 k/μL) compared to those with focal epilepsy (6.53 k/μL); the main difference was due to the number of monocytes. Conclusion. These findings raise the possibility that there are different neuro-immune profiles between patients with generalised and focal epilepsy.
Authors:
Rani A Sarkis; Lara Jehi; Diosely Silveira; Damir Janigro; Imad Najm
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-20
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  -     ISSN:  1294-9361     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Epilepsy Center/Neurological Institute, Cleveland Clinic.
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