| Patients with cystic fibrosis and normoglycemia exhibit diabetic glucose tolerance during pulmonary exacerbation. | |
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MedLine Citation:
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PMID: 20188638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with cystic fibrosis and normoglycemia (CF-NGT) have higher but still "normal" glucose levels in the Oral Glucose Tolerance Test (OGTT). Respiratory exacerbation is associated with metabolic stress. The objective of this study was to assess the glucose metabolism and its relation to the steady state pulmonary function (FEV1) in patients with CF-NGT, specifically during pulmonary exacerbations (PE). METHODS: CF-NGT patients who were not on steroids, underwent OGTT and intravenous glucose tolerance tests (IVGTT) during PE and 4weeks after complete recovery. RESULTS: Of the ten recruited patients two had diabetic OGTT and were excluded. The remaining normoglycemic patients displayed during PE a diabetic glucose tolerance with mean glucose levels of 233+/-8 and 262+/-11mg/dl at 90 and 120min respectively, compared with normal levels of 154+/-21and 126+/-20mg/dl (p<0.002) during the steady state. IVGTT showed a tendency to higher first phase insulin release during PE compared with the steady state.(min 3; 305+/-80 vs. 216+/-40pmol\l p=0.075). Finally, when relating the diabetic status to the general respiratory function we found a negative correlation between baseline FEV1 and glucose levels at 2h after OGTT during PE (r=-0.88, p=0.002). CONCLUSION: In this pilot study we show that during PE patients with CF and normal glucose tolerance exhibited early latent diabetic glucose intolerance. As this hyperglycemia presents in the later parts of the OGTT it probably results from insufficient second phase insulin secretion during PE. The negative correlation observed here between the diabetic glucose tolerance and FEV1 indicate the need of interventional studies using insulin during PE in non-diabetic patients to determine its potential benefit on the outcome from recurrent PEs. |
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Authors:
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Noa Nezer M Sc; David Shoseyov; Eitan Kerem; David Haim Zangen |
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Publication Detail:
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Type: Journal Article Date: 2010-02-25 |
Journal Detail:
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Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: 9 ISSN: 1873-5010 ISO Abbreviation: J. Cyst. Fibros. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: Netherlands |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
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Pediatric Endocrine Unit, Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, P.O. Box: 24035, Jerusalem 91240, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Glucose Cystic Fibrosis / blood, complications* Disease Progression Female Forced Expiratory Volume Glucose Intolerance / complications* Glucose Tolerance Test Humans Male Pilot Projects Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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