| Patients with autosomal dominant polycystic kidney disease have elevated fibroblast growth factor 23 levels and a renal leak of phosphate. | |
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MedLine Citation:
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PMID: 20944552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibroblast growth factor 23 (FGF23) and parathyroid hormone blood levels rise following progressive loss of renal function. Here we measured parameters of phosphate metabolism in 100 patients with autosomal dominant polycystic kidney disease (ADPKD) in stage 1 or 2 of chronic kidney disease, 20 patients with non-diabetic chronic kidney disease, and 26 with type 2 diabetes. Twenty healthy volunteers served as controls. The mean levels of FGF23 were significantly (4-fold) higher in ADPKD compared to non-diabetic and diabetic patients, and healthy volunteers. Mean serum phosphate levels were significantly lower in ADPKD patients compared to non-diabetic and diabetic patients, and the healthy volunteers. The prevalence of hypophosphatemia was 38, 25, 27, and 5% in ADPKD, non-diabetic and diabetic patients, and healthy volunteers, respectively. The tubular maximum of phosphate reabsorption per glomerular filtration rate was lowest in ADPKD patients with a significantly high positive correlation with serum phosphate levels. Estimated glomerular filtration rates were approximately 100 ml/min per 1.73 m² in all groups and parathyroid hormone and vitamin D metabolite levels were in the normal range. Thus, FGF23 was substantially elevated in ADPKD patients compared to other CKD patients matched for glomerular filtration rate, and was associated with increased renal phosphate excretion. The mechanism for this anomaly will require further study. |
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Authors:
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Ivana Pavik; Philippe Jaeger; Andreas D Kistler; Diane Poster; Fabienne Krauer; Claudia Cavelti-Weder; Katharina M Rentsch; Rudolf P Wüthrich; Andreas L Serra |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-13 |
Journal Detail:
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Title: Kidney international Volume: 79 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-30 Completed Date: 2011-04-27 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 234-40 Citation Subset: IM |
Affiliation:
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Institute of Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Calcifediol / blood Calcitriol / blood Case-Control Studies Diabetes Mellitus, Type 2 / blood, metabolism Female Fibroblast Growth Factors / blood* Glomerular Filtration Rate Humans Kidney / metabolism* Male Middle Aged Parathyroid Hormone / blood Phosphates / metabolism*, urine Polycystic Kidney, Autosomal Dominant / blood, metabolism*, physiopathology Renal Insufficiency, Chronic / blood, metabolism, physiopathology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/PTH protein, human; 0/Parathyroid Hormone; 0/Phosphates; 0/fibroblast growth factor 23; 19356-17-3/Calcifediol; 32222-06-3/Calcitriol; 62031-54-3/Fibroblast Growth Factors |
| Comments/Corrections | |
Comment In:
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Kidney Int. 2011 Sep;80(5):554-5; discussion 555
[PMID:
21841838
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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