Document Detail

Patients with acute coronary syndromes have low tissue factor activity and microparticle count, but normal concentration of tissue factor antigen in platelet free plasma: a pilot study.
MedLine Citation:
PMID:  19018869     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Tissue factor (TF) is a main initiator of coagulation cascade. Its determination in conditions of acute coronary syndrome is logistically difficult. Hence, in our study, the activity and the concentration of TF and the count of microparticles in the platelet free plasma (PFP) were determined. METHODS: Blood was drawn from both coronary sinus and femoral vein circulation in a cohort of 40 patients. TF activity was measured by activation of factor X in the presence of factor VIIa, whereas microparticles were detected using flow cytometry. TF antigen concentrations were determined using the ELISA test. RESULTS: TF activity in the stable angina subgroup was not significantly different from the control group (18.12 +/- 3.35 mOD/min vs. 17.72 +/- 4.05 mOD/min, respectively), but it was significantly lower in the unstable angina (7.62 +/- 4.19 mOD/min) and myocardial infarction (MI) (3.56 +/- 3.85 mOD/min) subgroups (P < 0.05). Results from the coronary sinus and femoral vein circulations were not significantly different. The count of microparticles decreased according to the severity of the acute coronary syndrome: control group, 520 +/- 172; stable angina subgroup, 532 +/- 167; unstable angina subgroup, 392 +/- 142; and MI subgroup, 165 +/- 30 (P < 0.05). There were no significant differences in concentrations of TF antigen in four subgroups. CONCLUSIONS: These results suggest that the procoagulant TF-bearing microparticles could be recruited from PFP by interaction with platelets and blood cells in the conditions of acute coronary syndrome.
Martin Maly; Ingrid Hrachovinova; Pavol Tomasov; Peter Salaj; Petr Hajek; Josef Veselka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-06
Journal Detail:
Title:  European journal of haematology     Volume:  82     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  IM    
Department of Cardiology, University Hospital Motol, 1st Medical Faculty, Prague, Czech Republic.
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MeSH Terms
Acute Coronary Syndrome / blood*
Autoantigens / blood*
Blood Platelets
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Middle Aged
Pilot Projects
Prospective Studies
Thromboplastin / analysis*,  immunology
Reg. No./Substance:
0/Autoantigens; 9035-58-9/Thromboplastin

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