Document Detail

Patients with psoriasis have a higher prevalence of parental cardiovascular disease.
MedLine Citation:
PMID:  21701147     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Parental history of cardiovascular disease (CVD) is an independent risk factor for offspring CVD. Patients with chronic plaque psoriasis have an intermediate risk of developing CVD.
OBJECTIVE: To investigate the prevalence of parental history of CVD in patients with psoriasis.
METHOD: A cross-sectional study on 236 adult patients with chronic plaque psoriasis and 246 controls was performed. Parental history of myocardial infarction and/or stroke was investigated by using a structured questionnaire. The accuracy of the self-reported information was confirmed by the hospital registry.
RESULTS: A positive parental history of maternal myocardial infarction was observed in 28/236 cases compared to 16/246 controls (11.8 vs. 6.5%; p = 0.04). A positive parental history of premature maternal myocardial infarction (i.e. <65 years) was observed in 16/236 cases compared to 3/246 controls (6.8 vs. 1.2%; p = 0.01). Moreover, a positive parental history of paternal stroke was observed in 25/236 cases compared to 14/246 controls (10.5 vs. 5.6%; p = 0.04). A positive parental history of psoriasis was higher in cases than in controls (35 vs. 2%; p < 0.001).
CONCLUSIONS: Parental history of CVD could also be investigated in patients with psoriasis for a more comprehensive estimation of their cardiovascular risk.
Paolo Gisondi; Camilla Dalle Vedove; Giampiero Girolomoni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-23
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  222     ISSN:  1421-9832     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-06     Completed Date:  2012-01-19     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  330-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
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MeSH Terms
Chronic Disease
Cross-Sectional Studies
Medical History Taking
Middle Aged
Myocardial Infarction / epidemiology*
Psoriasis / epidemiology*
Stroke / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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