| Patients with Partial Gastrectomy and Barrett Esophagus are in Higher Risk to Develop Esophageal Adenocarcinoma than those with Barretts without Gastrectomy. | |
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MedLine Citation:
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PMID: 22580662 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background/Aims: Duodenogastric reflux is a possible risk factor for esophageal adenocarcinoma (CA) development. Gastric surgery that destroys or distorts the pylorus is a good model to study the effects of duodenogastric reflux. To define the consequences of gastrectomy in patients with Barrett esophagus (BE). Methodology: Records of all BE/CA patients examined in Blackpool-Wyre-Fylde area were reviewed. All surviving patients completed validated questionnaires. Results: Gastrectomy was more prevalent in CA patients (14 (3.6%) BE vs. 15 (13.3%) CA, p=0.0002). Partial gastrectomy was more prevalent in CA patients, (7 (1.8%) BE vs. 10 (8.8%) CA, p=0.0004), while there was no difference in total gastrectomy between the two groups. Persistence of H. pylori infection after gastrectomy and smoking were more frequent among CA patients with gastrectomy. Mean follow-up time in patients with prior gastrectomy was 78 (SD=76.4) months for BE patients and 119.3 (SD=72.9) months for CA patients (p=0.07). In logistic regression analysis gastrectomy, in addition to old age, long-term reflux, absence of hiatal hernia and H. pylori infection were risk factors for CA. Conclusions: Gastrectomy and especially partial gastrectomy was more prevalent in CA patients. |
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Authors:
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Panagiotis Tsibouris; Mark T Hendrickse; Chrissostomos Kalantzis; Peter Et Isaacs |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 59 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2012 Jul-Aug |
Date Detail:
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Created Date: 2012-05-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 1118-22 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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