Document Detail


Patients with Early-Stage Myelodysplastic Syndromes Show Increased Frequency of CD4+CD25+CD127(low) Regulatory T Cells.
MedLine Citation:
PMID:  22890368     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Regulatory T cells (T(reg)) have often been ascribed a role in the pathophysiology of several neoplastic diseases considering their potential ability to suppress anti-tumor immunity. This is particularly the case in myelodysplastic syndromes (MDS), which are clonal hematologic disorders characterized by marked immune dysregulation. We analyzed T(reg) frequencies in a cohort of 36 patients with early-stage MDS using a flow-cytometric approach based on the concomitant expression of CD25 and CD127. MDS patients showed a higher frequency of CD4+CD25(high)+CD127(low) T(reg) than healthy controls (1.51 vs. 1.14%), with no specific effect of patient- and disease-related factors. Our data point to impaired anti-tumor immunity in patients with MDS, even in the early stage, which has already been noted in other clonal disorders.
Authors:
Claudio Fozza; Francesco Longu; Salvatore Contini; Antonio Galleu; Patrizia Virdis; Silvana Bonfigli; Marco Murineddu; Attilio Gabbas; Maurizio Longinotti
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-10
Journal Detail:
Title:  Acta haematologica     Volume:  128     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  178-182     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Hematology, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
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